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Table 2 Longitudinal mean changes and intraclass correlation coefficients (ICC) of KCCQ subscales, MAHFER study

From: Validation of heart failure quality of life tool and usage to predict all-cause mortality in acute heart failure in Uganda: the Mbarara heart failure registry (MAHFER)

HQOL measure

Mean (SD)

Mean change vs. Baseline (SE)

P-value trend

ICC (95% CI)

KCCQ

 Physical limitation

   

0.16 (0.05, 0.41)

  Baseline

12.6 (18.9)

–

–

 

  Month 1

41.9 (28.9)

−29.4 (3.0)

<  0.001

 

  Month 3

41.2 (25.9)

−28.8 (3.5)

<  0.001

 

 Symptom stability

   

0.24 (0.08, 0.53)

  Baseline

51.5 (21.1)

–

–

 

  Month 1

48.5 (20.7)

2.9 (2.9)

0.450

 

  Month 3

46.1 (21.7)

5.4 (3.7)

0.142

 

 Symptom frequency

   

0.14 (0.03, 0.45)

  Baseline

38.4 (22.9)

–

–

 

  Month 1

47.3 (30.9)

−9.1 (3.5)

0.046

 

  Month 3

52.9 (32.0)

−14.5 (4.2)

0.003

 

 Symptom burden

   

0.08 (0.01, 0.56)

  Baseline

40.6 (24.7)

–

–

 

  Month 1

42.7 (33.3)

−8.7 (3.8)

0.046

 

  Month 3

52.4 (35.3)

−18.5 (4.7)

0.001

 

 Total symptom score

   

0.11 (0.02, 0.48)

  Baseline

39.5 (23.8)

–

–

 

  Month 1

45.0 (31.9)

−8.8 (3.6)

0.046

 

  Month 3

52.7 (33.4)

−16.5 (4.4)

0.002

 

 Self-efficacy

   

0.45 (0.29, 0.62)

  Baseline

58.7 (21.7)

–

–

 

  Month 1

31.5 (24.3)

27.2 (3.1)

<  0.001

 

  Month 3

25.0 (24.4)

33.6 (3.8)

<  0.001

 

 Quality of life

   

0.14 (0.03, 0.44)

  Baseline

23.1 (16.1)

–

–

 

  Month 1

14.5 (22.7)

8.7 (2.5)

0.005

 

  Month 3

13.1 (22.2)

10.2 (2.9)

0.024

 

 Social limitation

   

0.13 (0.03, 0.41)

  Baseline

11.9 (18.7)

–

–

 

  Month 1

13.0 (28.9)

−1.2 (3.0)

0.008

 

  Month 3

13.8 (26.9)

−2.0 (3.5)

0.905

 

 Overall summary score

   

0.13 (0.03, 0.43)

  Baseline

21.8 (15.8)

–

–

 

  Month 1

28.6 (23.4)

−7.7 (2.5)

0.008

 

  Month 3

30.2 (21.4)

−9.3 (2.9)

0.002

 

 Clinical summary score

   

0.16 (0.04, 0.44)

  Baseline

26.0 (18.6)

–

–

 

  Month 1

43.4 (25.3)

−19.2 (2.8)

<  0.001

 

  Month 3

46.9 (24.9)

−22.6 (3.4)

<  0.001

 
  1. HQOL Health related quality of life, KCCQ Kansas City Cardiomyopathy Questionnaire, SD Standard deviation, SE Standard Error, ICC Intraclass Correlation Coefficient