Skip to main content

Table 5 Changing of patient’s characteristics: comparison of biochemical values before and after dietary intervention

From: Dietary intervention with a specific micronutrient combination for the treatment of patients with cardiac arrhythmias: the impact on insulin resistance and left ventricular function

 

Verum (n = 29) x ± SD

Placebo (n = 25) x ± SD

Baseline

Week 6

Diff

Baseline

Week 6

Diff

CrP (nmol/l)

26.0 ± 28.7

24.8 ± 22.6

−1.22 ± 23.37

20.8 ± 19.8

29.8 ± 42.1

9.07 ± 39.52

  < 10 nmol/l (n/%)

9 (31.0%)

9 (31.0%)

–

10 (40.0%)

12 (48.0%)

–

 10–30 nmol/l (n/%)

13 (44.8%)

13 (44.8%)

10 (40.0%)

6 (24.0%)

  > 30 nmol/l (n/%)

7 (24.1%)

7 (24.1%)

5 (20.0%)

7 (28.0%)

FPG (mmol/l)

5.49 ± 1.58

5.30 ± 1.28

− 0.20 ± 0.75

5.35 ± 0.65

5.15 ± 0.77

−0.20 ± 0.63#

  < 5.6 mmol/l

4.76 ± 0.54

4.79 ± 0.62

0.03 ± 0.39

5.04 ± 0.27

4.91 ± 0.70

− 0.13 ± 0.58

  ≥ 5.6 mmol/l

7.12 ± 1.94

6.42 ± 1.67

−0.70 ± 1.10

6.15 ± 0.65

5.79 ± 0.56

−0.36 ± 0.75

HbA1c (%)

5.77 ± 0.68

5.76 ± 0.63

−0.01 ± 0.35

5.64 ± 0.39

5.66 ± 0.33

0.02 ± 0.39

F Insulin (pmol/l)a

113.9 ± 127.5

89.5 ± 75.8

− 24.4 ± 73.4

83.6 ± 44.9

71.3 ± 51.3

−12.3 ± 54.0

  < 58 pmol/l (n/%)

10 (34.5%)

11 (37.9%)

–

8 (32.0%)

10 (40.0%)

–

  < 58 pmol/l

39.2 ± 9.9

44.7 ± 18.4

5.2 ± 19.5

41.3 ± 13.5

40.4 ± 13.3

− 0.9 ± 16.0

  ≥ 58 pmol/l

153.1 ± 143.2

113.1 ± 84.0

−39.9 ± 86.3#

103.5 ± 40.0

85.9 ± 56.3

− 17.7 ± 64.6

HOMA-IRa

4.93 ± 9.18

3.39 ± 4.00

− 1.54 ± 5.69#

2.97 ± 1.86

2.50 ± 2.17

−0.47 ± 2.26

  ≤ 2.5 (n/%)

15 (51.7%)

20 (69.0%)

–

14 (56.0%)

18 (72.0%)

–

  ≤ 2.5

1.55 ± 0.52

1.57 ± 0.59

0.03 ± 0.56

1.66 ± 0.52

1.95 ± 2.19

0.29 ± 2.02

  > 2.5

8.56 ± 12.40

5.34 ± 5.12

− 3.22 ± 7.97

4.64 ± 1.60

3.20 ± 2.03

−1.44 ± 2.28

Na (mmol/l)

143.0 ± 4.5

142.2 ± 2.7

−0.76 ± 4.25

141.9 ± 2.5

141.6 ± 2.8

−0.28 ± 2.51

  < 140 mmol/l

138.0 ± 1.2

139.0 ± 3.5

1.00 ± 2.83

138.4 ± 0.9

138.8 ± 4.4

0.40 ± 4.22

  ≥ 140 mmol/l

143.8 ± 4.3

142.8 ± 2.2

− 1.04 ± 4.41

142.8 ± 2.0

142.4 ± 1.7

− 0.45 ± 2.01

K (mmol/l)

4.44 ± 0.53

4.55 ± 0.43

0.11 ± 0.44

4.59 ± 0.37

4.50 ± 0.31

−0.09 ± 0.33*

  < 4.0 mmol/l

3.72 ± 0.17

4.08 ± 0.34

0.35 ± 0.26

3.70

4.10

0.40

  ≥ 4.0 mmol/l

4.56 ± 0.47

4.62 ± 0.40

0.07 ± 0.45

4.63 ± 0.33

4.52 ± 0.31

− 0.11 ± 0.32

Mg (mmol/l)

0.845 ± 0.069

0.858 ± 0.068

0.013 ± 0.047

0.874 ± 0.084

0.851 ± 0.068

−0.024 ± 0.056#**

  < 0.75 mmol/l

0.727 ± 0.023

0.773 ± 0.021

0.048 ± 0.035

0.72

0.77

0.05

  ≥ 0.75 mmol/l

0.859 ± 0.058

0.867 ± 0.068

0.009 ± 0.047

0.881 ± 0.079

0.854 ± 0.068

− 0.027 ± 0.055##**

Cl (mmol/l)

102.0 ± 3.4

100.9 ± 2.6

−1.03 ± 3.80

101.4 ± 2.6

101.4 ± 3.2

0.00 ± 3.20

  < 100 mmol/l

98.0 ± 1.2

99.6 ± 2.4

1.57 ± 2.51

97.8 ± 1.0

100.2 ± 2.5

2.33 ± 2.88

  ≥ 100 mmol/l

103.2 ± 2.8

101.4 ± 2.5

−1.86 ± 3.81#

102.6 ± 1.8

101.8 ± 3.4

−0.74 ± 3.00

Creatinine (μmol/l)

77.4 ± 14.6

76.4 ± 14.9

−0.95 ± 6.98

76.6 ± 17.4

75.3 ± 16.4

−1.31 ± 7.02

GFR (ml/min)

83.6 ± 13.9

85.4 ± 14.9

1.79 ± 8.09

86.1 ± 16.0

86.8 ± 16.3

0.76 ± 6.48

TC (mmo/l)

4.97 ± 1.00

5.12 ± 1.09

0.15 ± 0.66

5.25 ± 0.94

5.10 ± 1.04

−0.15 ± 0.69

  ≥ 5.2 mmol/l

5.74 ± 0.63

6.08 ± 0.79

0.34 ± 0.85

5.86 ± 0.75

5.89 ± 0.67

0.03 ± 0.37

LDL-C (mmol/l)

3.14 ± 0.97

3.10 ± 0.83

− 0.04 ± 0.44

3.39 ± 0.92

3.30 ± 0.97

−0.09 ± 0.45

  < 2.6 mmol/l

2.02 ± 0.27

2.27 ± 0.48

0.25 ± 0.45

2.11 ± 0.56

2.33 ± 0.32

0.22 ± 0.25

  ≥ 2.6 mmol/l

3.59 ± 0.76

3.43 ± 0.70

−0.15 ± 0.40

3.64 ± 0.76

3.48 ± 0.94

−0.15 ± 0.46

  < 3.3 mmol/l

2.43 ± 0.48

2.59 ± 0.51

0.16 ± 0.36

2.72 ± 0.57*

2.67 ± 0.40

− 0.05 ± 0.33

  ≥ 3.3 mmol/l

4.08 ± 0.55

3.78 ± 0.68

− 0.30 ± 0.41#

4.01 ± 0.71

3.88 ± 0.99

− 0.14 ± 0.54

HDL-C (mmol/l)

1.40 ± 0.41

1.39 ± 0.43

−0.01 ± 0.17

1.45 ± 0.47

1.40 ± 0.42

−0.05 ± 0.17

TG (mmol/l)

1.56 ± 0.77

1.97 ± 1.86

0.42 ± 1.30#

1.34 ± 0.53

1.36 ± 0.50

0.02 ± 0.58

  ≥ 1.7 mmol/l

2.63 ± 0.57

3.71 ± 2.95

1.08 ± 2.41

2.08 ± 0.28*

1.71 ± 0.61

−0.37 ± 0.76

Uric acid (μmol/l)

338 ± 90

331 ± 80

− 7.2 ± 42.1

315 ± 100

308 ± 91

− 6.9 ± 39.9

Gamma-GT (μkat/l)

0.64 ± 0.83

0.63 ± 0.72

−0.01 ± 0.17

0.53 ± 0.29

0.52 ± 0.26

−0.01 ± 0.17

ASAT (μkat/l)

0.42 ± 0.20

0.42 ± 0.11

0.00 ± 0.14

0.40 ± 0.11

0.40 ± 0.13

0.00 ± 0.09

ALAT (μkat/l)

0.47 ± 0.24

0.46 ± 0.21

− 0.02 ± 0.16

0.43 ± 0.26

0.45 ± 0.28

0.02 ± 0.11

TSH (μIU/ml)

2.15 ± 1.17

1.96 ± 1.06

−0.19 ± 0.52#

2.19 ± 1.20

1.92 ± 1.00

−0.28 ± 0.57#

24 h urinary collection

 Na (mmol/24 h)

193.7 ± 73.6

186.7 ± 76.0

−7.0 ± 79.7

167.9 ± 53.5

177.4 ± 64.1

9.5 ± 46.8

 K (mmol/24 h)

68.2 ± 25.3

76.6 ± 26.2

8.4 ± 28.0

67.3 ± 19.3

71.6 ± 22.5

4.2 ± 18.0

 K i.S./K (24 h)

0.072 ± 0.023

0.067 ± 0.027

− 0.005 ± 0.028

0.076 ± 0.034

0.069 ± 0.021

−0.008 ± 0.030

 Mg (mmol/24 h)

4.03 ± 1.14

4.79 ± 1.79

0.76 ± 1.85#

3.78 ± 1.45

3.86 ± 1.88

0.08 ± 1.75*

 Mg i.S./Mg (24 h)

0.227 ± 0.070

0.221 ± 0.162

−0.006 ± 0.180

0.260 ± 0.095

0.268 ± 0.121

0.008 ± 0.093

 Cl (mmol/24 h)

175.6 ± 70.2

174.9 ± 76.9

−0.72 ± 74.63

153.5 ± 54.9

161.2 ± 70.7

7.72 ± 43.40

 Albumin (mg/24 h)

10.8 ± 19.2

12.0 ± 26.4

1.17 ± 15.42

9.5 ± 17.2

11.7 ± 18.8

2.24 ± 5.88

 Albumin/crea (24 h)

0.82 ± 1.40

0.80 ± 1.36

−0.02 ± 0.36

0.77 ± 1.31

0.96 ± 1.55

0.20 ± 0.48

  1. Abbreviations: HK haematocrit, MCHC mean corpuscular/cellular haemoglobin concentration, MCV mean corpuscular/cell volume, CrP C reactive protein, FPG fasting plasma glucose, HbA1c glycated haemoglobin A1c, F Insulin fasting insulin, HOMA-IR homeostasis model assessment-insulin resistance, Na natrium, K potassium, MG magnesium, Cl chloride, GFR glomerular filtration rate, TC total cholesterol, LDL-C LDL-cholesterol, HDL-C HDL-cholesterol, TG triglycerides, ASAT aspartate-aminotranferase, ALAT alanin-aminotranferase, TSH thyroid stimulating hormone, # p < 0.05 within the group, ## p < 0.01 within the group, * p < 0.05 between the groups, ** p < 0.01 between the groups, aLarge variation coefficients indicate statistical outliers. By sensitivity analyses the influence of these statistical outliers was checked. The results in the full analysis set were confirmed