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Fig. 5 | BMC Cardiovascular Disorders

Fig. 5

From: Metformin regulates atrial SK2 and SK3 expression through inhibiting the PKC/ERK signaling pathway in type 2 diabetic rats

Fig. 5

A proposed pathway for the protective effects of metformin against DM-induced disorders on atrial SK2 and SK3 channels. DM induces an excessive activitiy of PKC which is followed by a sequential activation of ERK and causes disorders of atrial SK2 and SK3 channels. Metformin treatment leads to a sequential inhibition on the activities of PKC and ERK and results in an improvement on the disorders

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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