Parameters | Grade 0 (n = 46) | Grade 1 (n = 44) | Grade 2 (n = 62) | Grade 3 (n = 39) | r | P value |
---|---|---|---|---|---|---|
Male (%) | 89.1 | 72.7 | 61.3 | 46.2 | − 0.319 | < 0.001* |
Age (years) | 48.0 ± 7.9 | 50.7 ± 9.7 | 49.8 ± 9.2 | 48.8 ± 9.0 | 0.107 | 0.139 |
BMI (kg/m2) | 25.6 ± 3.1 | 25.3 ± 2.9 | 24.3 ± 2.7 | 24.1 ± 2.9 | −0.176 | 0.015* |
Current smokers (%) | 34.6 | 24.4 | 26.9 | 14.1 | −0.222 | 0.002* |
Current drinkers (%) | 27.1 | 31.4 | 28.6 | 12.9 | −0.161 | 0.026* |
ALT (u/L) | 30.5 (19.8, 42.0) | 25.5 (21.0, 35.8) | 22.0 (18.0, 30.3) | 19.0 (14.0, 29.0) | −0.281 | < 0.001* |
AST (u/L) | 20.8 ± 7.0 | 19.6 ± 6.0 | 18.8 ± 4.4 | 18.1 ± 4.6 | −0.127 | 0.080 |
γ-GT (u/L) | 44.0 (27.8, 72.8) | 34.0 (23.3, 68.5) | 25.0 (18.0, 43.8) | 24.0 (15.0, 37.0) | −0.345 | < 0.001* |
TC (mmol/ L) | 5.20 ± 1.36 | 5.10 ± 0.85 | 4.84 ± 0.81 | 5.17 ± 1.09 | −0.026 | 0.719 |
TG (mmol/ L) | 2.78 (1.77, 4.01) | 2.53 (1.78, 3.81) | 2.11 (1.45, 2.67) | 2.03 (1.52, 2.71) | −0.231 | 0.001* |
HDL-C (mmol/ L) | 1.05 ± 0.27 | 1.09 ± 0.20 | 1.24 ± 0.28 | 1.27 ± 0.30 | 0.326 | < 0.001* |
LDL-C (mmol/ L) | 2.60 ± 0.84 | 2.53 ± 0.54 | 2.36 ± 0.51 | 2.55 ± 0.67 | −0.042 | 0.569 |
TC/HDL-C | 5.21 ± 1.79 | 4.81 ± 1.19 | 4.09 ± 1.16 | 4.22 ± 1.24 | −0.291 | < 0.001* |
Lipoprotein(a) (mg/L) | 61.5 (37.8, 131.0) | 64.0 (49.0, 125.0) | 65.5 (44.8, 116.5) | 73.0 (37.0, 122.0) | −0.006 | 0.934 |
TSH (μIU/ml) | 2.02 (1.44, 2.83) | 2.03 (1.47, 2.64) | 2.16 (1.56, 3.53) | 2.16 (1.48, 3.25) | 0.093 | 0.201 |
Fasting glucose (mmol/ L) | 6.28 ± 1.57 | 5.97 ± 1.16 | 5.64 ± 1.10 | 5.45 ± 0.51 | −0.219 | 0.002* |
HbA1c(%) | 5.85 ± 1.01 | 5.81 ± 0.98 | 5.45 ± 0.69 | 5.45 ± 0.44 | −0.173 | 0.018* |
Fasting insulin (mIU/L) | 7.90 (5.46, 10.40) | 7.40 (4.86, 9.92) | 5.70 (4.51, 6.78) | 5.20 (4.00, 6.89) | −0.322 | < 0.001* |
HOMA-IR | 2.17 (1.38, 2.88) | 1.91 (1.36, 2.47) | 1.29 (1.06, 1.63) | 1.37 (0.95, 1.60) | −0.365 | < 0.001* |
NAFLD (%) | 54.5 | 24.2 | 18.2 | 3.0 | −0.337 | < 0.001* |
VAT volume (cm3) | 1462 (1214, 1833) | 1571 (1042, 1900) | 1339 (950, 1731) | 1084 (766, 1450) | −0.239 | 0.001* |
SAT volume (cm3) | 1693 (1354, 2021) | 1712 (1396, 2190) | 1781 (1516, 2183) | 1841 (1490, 2375) | 0.116 | 0.109 |