Variables | Univariate HR | P value | Multivariate HR | P value |
---|---|---|---|---|
Age (per 5 years) | 1.23 (1.18–1.29) | < 0.001 | 1.11 (1.05–1.17) | < 0.001 |
Female sex | 1.50 (1.25–1.83) | < 0.001 | ||
Hypertension | 1.47 (1.19–1.81) | < 0.001 | ||
Diabetes Mellitus | 1.46 (1.20–1.77) | < 0.001 | 1.26 (1.03–1.54) | 0.026 |
COPD | 1.76 (1.41–2.19) | < 0.001 | 1.63 (1.28–2.07) | < 0.001 |
HFPEF | 1.60 (1.30–1.97) | < 0.001 | 1.67 (1.31–2.18) | < 0.001 |
Ischaemic aetiology | 1.14 (0.95–1.38) | 0.166 | 1.40 (1.12–1.73) | 0.003 |
NYHA class III-IV | 2.55 (2.10–3.09) | < 0.001 | 1.64 (1.33–2.03) | < 0.001 |
Systolic BP (per 10 mmHg) | 0.97 (0.93–1.01) | 0.123 | ||
Heart rate (per 10 bpm) | 1.09 (1.03–1.16) | 0.005 | ||
BMI (per 1 kg/m2) | 0.99 (0.97–1.01) | 0.21 | ||
ACE-I or ARB | 0.47 (0.37–0.61) | < 0.001 | ||
Beta blockers | 0.46 (0.36–0.58) | < 0.001 | 0.71 (0.54–0.93) | 0.013 |
Diuretics | 3.47 (2.28–5.28) | < 0.001 | 2.53 (1.64–3.91) | < 0.001 |
MRAs | 1.10 (0.91–1.33) | 0.327 | ||
Digoxin | 1.13 (0.91–1.40) | 0.263 | ||
ICD | 0.91 (0.66–1.27) | 0.581 | ||
Iron deficiency | 1.21 (1.00–1.47) | 0.047 | 0.96 (0.78–1.17) | 0.677 |
Haemoglobin (per 1 g/dL) | 0.84 (0.80–0.89) | < 0.001 | ||
Log NT-proBNP (per 1 SD) | 2.00 (1.87–2.15) | < 0.001 | 1.49 (1.32–1.68) | < 0.001 |
Sodium (per 5 mmol/L) | 0.93 (0.81–1.07) | 0.328 | ||
eGFR (per 5 ml/min/1.73m2) | 0.95 (0.93–0.97) | < 0.001 |