Skip to main content

Table 1 Baseline variables according to iron deficiency

From: Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study

Variables Overall N = 1684 No ID N = 786 ID N = 898 P value
Age (years) 72 (61–79) 70 (58–78) 73 (63–79) < 0.0001
Female gender 588 (35) 207 (26) 381 (42) < 0.0001
BMI (kg/m2) 27 (24–30) 30 (27–34) 31 (27–36) 0.011
Systolic BP (mm Hg) 120 (108–139) 118 (105–133) 125 (110–140) < 0.0001
Heart rate (bpm) 70 (62–80) 70 (60–80) 70 (62–80) 0.398
NYHA Class III-IV 592 (35) 218 (28) 374 (42) < 0.0001
LVEF (%) 35 (27–50) 35 (27–48) 36 (28–53) 0.032
HFPEF 428 (25) 182 (23) 246 (27) 0.046
Ischaemic aetiology 738 (44) 331 (42) 407 (45) 0.185
Hypertension 1136 (68) 492 (63) 644 (72) < 0.0001
Diabetes Mellitus 639 (38) 262 (33) 377 (42) < 0.0001
COPD 318 (19) 158 (20) 160 (18) 0.232
Treatment
 ACE-I or ARB 1457 (87) 695 (89) 762 (85) 0.019
 Beta blockers 1474 (88) 690 (88) 784 (87) 0.766
 MRAs 716 (43) 357 (45) 359 (40) 0.024
 Digoxin 395 (23) 184 (23) 211 (24) 0.966
 Oral anticoagulation 755 (45) 356 (45) 399 (44) 0.723
 Antiplatelet 879 (52) 412 (52) 467 (52) 0.884
 Diuretics 1458 (87) 661 (84) 797 (89) 0.001
 ICD 136 (8) 64 (8) 72 (8) 0.933
 Resynchronization 77 (5) 35 (5) 42 (5) 0.826
Laboratory values
 Haemoglobin (g/dL) 13.0 (11.7–14.3) 13.4 (12.0–14.7) 12.7 (11.5–13.9) < 0.0001
 eGFR (ml/min/1.73 m2) 53 (37–71) 56 (38–75) 52 (36–68) 0.032
 Ferritin (ng/mL) 155 (72–276) 276 (172–435) 76 (43–141) < 0.0001
 Transferrin (mg/dL) 261 (224–313) 245 (213–288) 276 (239–330) < 0.0001
 Serum iron (ug/dL) 73 (51–99) 90 (71–116) 59 (44–79) < 0.0001
 TSAT (%) 20 (15–28) 26 (22–34) 16 (12–19) < 0.0001
 NTproBNP (ng/L) 1355 (536–3171) 1111 (488–2747) 1584 (609–3597) < 0.0001
 Sodium (mmol/L) 140 (138–142) 140 (138–142) 140 (138–142) 0.011
  1. Continuous variables are expressed as median and interquartile range (IQR). Categorical variables are expressed as number and percentage
  2. ID Iron deficiency, BMI Body mass index, NYHA New York Heart Association, LVEF Left ventricular ejection fraction, HFPEF Heart failure with preserved ejection fraction, COPD Chronic obstructive pulmonary disease, ACE-I Angiotensin converting enzyme inhibitor, ARB Angiotensin II receptor blocker, MRA Mineralocorticoid receptor antagonist, ICD Implantable cardioverter defibrillator, eGFR estimated glomerular filtration rate, TSAT Transferrin saturation, NTproBNP N-terminal pro-brain natriuretic peptide