Table 1 Baseline variables according to iron deficiency
Variables | Overall N = 1684 | No ID N = 786 | ID N = 898 | P value |
|---|---|---|---|---|
Age (years) | 72 (61–79) | 70 (58–78) | 73 (63–79) | < 0.0001 |
Female gender | 588 (35) | 207 (26) | 381 (42) | < 0.0001 |
BMI (kg/m2) | 27 (24–30) | 30 (27–34) | 31 (27–36) | 0.011 |
Systolic BP (mm Hg) | 120 (108–139) | 118 (105–133) | 125 (110–140) | < 0.0001 |
Heart rate (bpm) | 70 (62–80) | 70 (60–80) | 70 (62–80) | 0.398 |
NYHA Class III-IV | 592 (35) | 218 (28) | 374 (42) | < 0.0001 |
LVEF (%) | 35 (27–50) | 35 (27–48) | 36 (28–53) | 0.032 |
HFPEF | 428 (25) | 182 (23) | 246 (27) | 0.046 |
Ischaemic aetiology | 738 (44) | 331 (42) | 407 (45) | 0.185 |
Hypertension | 1136 (68) | 492 (63) | 644 (72) | < 0.0001 |
Diabetes Mellitus | 639 (38) | 262 (33) | 377 (42) | < 0.0001 |
COPD | 318 (19) | 158 (20) | 160 (18) | 0.232 |
Treatment | ||||
ACE-I or ARB | 1457 (87) | 695 (89) | 762 (85) | 0.019 |
Beta blockers | 1474 (88) | 690 (88) | 784 (87) | 0.766 |
MRAs | 716 (43) | 357 (45) | 359 (40) | 0.024 |
Digoxin | 395 (23) | 184 (23) | 211 (24) | 0.966 |
Oral anticoagulation | 755 (45) | 356 (45) | 399 (44) | 0.723 |
Antiplatelet | 879 (52) | 412 (52) | 467 (52) | 0.884 |
Diuretics | 1458 (87) | 661 (84) | 797 (89) | 0.001 |
ICD | 136 (8) | 64 (8) | 72 (8) | 0.933 |
Resynchronization | 77 (5) | 35 (5) | 42 (5) | 0.826 |
Laboratory values | ||||
Haemoglobin (g/dL) | 13.0 (11.7–14.3) | 13.4 (12.0–14.7) | 12.7 (11.5–13.9) | < 0.0001 |
eGFR (ml/min/1.73 m2) | 53 (37–71) | 56 (38–75) | 52 (36–68) | 0.032 |
Ferritin (ng/mL) | 155 (72–276) | 276 (172–435) | 76 (43–141) | < 0.0001 |
Transferrin (mg/dL) | 261 (224–313) | 245 (213–288) | 276 (239–330) | < 0.0001 |
Serum iron (ug/dL) | 73 (51–99) | 90 (71–116) | 59 (44–79) | < 0.0001 |
TSAT (%) | 20 (15–28) | 26 (22–34) | 16 (12–19) | < 0.0001 |
NTproBNP (ng/L) | 1355 (536–3171) | 1111 (488–2747) | 1584 (609–3597) | < 0.0001 |
Sodium (mmol/L) | 140 (138–142) | 140 (138–142) | 140 (138–142) | 0.011 |