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Table 1 Regulation and function of specific long noncoding RNA in DCM

From: Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy

LncRNAs Models Species Regulation during DCM Function in DCM References
H19 STZ-included T1DM Rats Down Suppress oxidative stress, inflammation, apoptosis, and autophagy [57, 58]
MALATI STZ-included T1DM Rats Up Suppress inflammation and apoptosis [15, 84]
MIAT STZ-included T1DM Rats Up Decrease apoptosis [37]
SENCR db/db T2DM Mice Down Promote proliferation and migration of smooth muscle cells [87]
MT-LIPCAR T2DM Humans Down Not available [13]
  1. DCM diabetic cardiomyopathy, LncRNAs long noncoding RNAs, STZ streptozocin, MALATI metastasis-associated lung adenocarcinoma transcript 1, MIAT myocardial infarction-associated transcript, SENCR smooth muscle and endothelial cell-enriched migration/defferentiation-associated long noncoding RNA, MT-LIPCAR the mitochondrially encoded long non-coding cardiac associated RNA