Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy

Table 1 Regulation and function of specific long noncoding RNA in DCM

LncRNAs	Models	Species	Regulation during DCM	Function in DCM	References
H19	STZ-included T1DM	Rats	Down	Suppress oxidative stress, inflammation, apoptosis, and autophagy	[57, 58]
MALATI	STZ-included T1DM	Rats	Up	Suppress inflammation and apoptosis	[15, 84]
MIAT	STZ-included T1DM	Rats	Up	Decrease apoptosis	[37]
SENCR	db/db T2DM	Mice	Down	Promote proliferation and migration of smooth muscle cells	[87]
MT-LIPCAR	T2DM	Humans	Down	Not available	[13]

DCM diabetic cardiomyopathy, LncRNAs long noncoding RNAs, STZ streptozocin, MALATI metastasis-associated lung adenocarcinoma transcript 1, MIAT myocardial infarction-associated transcript, SENCR smooth muscle and endothelial cell-enriched migration/defferentiation-associated long noncoding RNA, MT-LIPCAR the mitochondrially encoded long non-coding cardiac associated RNA

ISSN: 1471-2261