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Fig. 2 | BMC Cardiovascular Disorders

Fig. 2

From: Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target

Fig. 2

RTK phosphorylation in a pig model of ischemia-reperfusion injury. A phospho-RTK array analysis addressing the phosphorylation of 49 RTKs was carried out for heart samples from a pig model of ischemia-reperfusion injury. Control pigs underwent the same anesthetic protocol as the ischema-reperfusion-injured pigs. a The intensity of the dots in the phospho-array were quantified by densitometry and normalized to each array’s sum of intensities. The resulting values were scaled according to the highest value set to one. Normalized phosphorylation values of each receptor with at least two non-zero results per each treatment are shown (mean + SD). b The same set of normalized phospho-RTK dot intensities were visualized as a heatmap. Receptors with at least two samples with non-zero results per each treatment were included, and were clustered using the maximum distance method. White tiles depict missing data for few samples. Asterisk indicates significant difference in phosphorylation (P < 0.05) for comparison of control samples to ischemia-reperfusion samples

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