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Table 2 Discriminations of CONFIRM score and GEM in individuals with 0 and 1 RF

From: Coronary calcium score improves the estimation for pretest probability of obstructive coronary artery disease and avoids unnecessary testing in individuals at low extreme of traditional risk factor burden: validation and comparison of CONFIRM score and genders extended model

  AUC IDI
Statistic 95% CI P value PTP Statisticb P value
Positive patientsa Negative patients
0 RF
 CONFIRM score 0.756 0.731 to 0.781 < 0.0001 44% 18% 5% < 0.0001
 GEM 0.843 0.820 to 0.866 46% 15%
1 RF
 CONFIRM score 0.762 0.742 to 0.783 < 0.0001 48% 22% 8% < 0.0001
 GEM 0.823 0.804 to 0.841 55% 21%
  1. AUC area under the receiver operating characteristic curve, IDI integrated discrimination improvement, CI confidence interval, other abbreviations as in Table 1
  2. aObstructive CAD was defined as present if an individuals had at least one lesion with ≥50% diameter stenosis or any non-assessable segments due to severe calcification on CCTA
  3. bCompared to CONFIRM score, the IDI of GEM = [P(GEM|Positive)- P(GEM|Positive)]-[P(CONFIRM score|Negative)- P(CONFIRM score|Negative)]