A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population

Table 4 Gene-sex, gene-hypertension, and gene-diabetes interactions of rs7396366 in patients with CAD and controls

Variables		Controls	CAD cases	OR (95% CI)	P	Adjusted OR^a (95% CI)	P
Variables		n (%)	n (%)	OR (95% CI)	P	Adjusted OR^a (95% CI)	P
Rs7396366	Sex
GG	Female	100 (26.9)	65 (19.4)	0.66 (0.46–0.93)	.019	0.58 (0.37–0.91)	.018
GG	Male	106 (28.5)	97 (29.0)	1.02 (0.74–1.42)	.892	1.02 (0.67–1.54)	.929
GT + TT	Female	98 (26.3)	74 (22.1)	0.79 (0.56–1.12)	.188	0.75 (0.48–1.16)	.198
GT + TT	Male	68 (18.3)	99 (29.6)	1.88 (1.32–2.67)	<.001	2.29 (1.44–3.59)	<.001
Rs7396366	Hypertension
GG	No	93 (25.0)	43 (12.8)	0.44 (0.30–0.66)	<.001	0.52 (0.32–0.84)	.007
GG	Yes	113 (30.4)	119 (35.5)	1.26 (0.92–1.73)	.146	0.97 (0.66–1.43)	.876
GT + TT	No	104 (28.0)	47 (14.0)	0.42 (0.29–0.62)	<.001	1.13 (0.68–1.89)	.641
GT + TT	Yes	62 (16.7)	126 (37.6)	3.01 (2.12–4.28)	<.001	1.50 (1.02–2.21)	.038
Rs7396366	T2DM
GG	No	173 (46.5)	122 (36.4)	0.66 (0.49–0.89)	.007	0.68 (0.46–0.99)	.042
GG	Yes	33 (8.9)	40 (11.9)	1.39 (0.86–2.27)	.216	0.91 (0.50–1.64)	.748
GT + TT	No	141 (37.9)	121 (36.1)	0.93 (0.68–1.26)	.624	1.13 (0.77–1.65)	.545
GT + TT	Yes	25 (6.7)	52 (15.5)	2.55 (1.54–4.21)	<.001	2.33 (1.24–4.38)	.009

Abbreviations: OR odds ratio, CI, confidence interval
^aLogistic regression model, adjusted by age, sex, hypertension, diabetes, smoking, BMI, and fasting plasma glucose

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