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Table 4 Gene-sex, gene-hypertension, and gene-diabetes interactions of rs7396366 in patients with CAD and controls

From: A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population

Variables   Controls CAD cases OR (95% CI) P Adjusted ORa (95% CI) P
n (%) n (%)
Rs7396366 Sex
GG Female 100 (26.9) 65 (19.4) 0.66 (0.46–0.93) .019 0.58 (0.37–0.91) .018
GG Male 106 (28.5) 97 (29.0) 1.02 (0.74–1.42) .892 1.02 (0.67–1.54) .929
GT + TT Female 98 (26.3) 74 (22.1) 0.79 (0.56–1.12) .188 0.75 (0.48–1.16) .198
GT + TT Male 68 (18.3) 99 (29.6) 1.88 (1.32–2.67) <.001 2.29 (1.44–3.59) <.001
Rs7396366 Hypertension
GG No 93 (25.0) 43 (12.8) 0.44 (0.30–0.66) <.001 0.52 (0.32–0.84) .007
GG Yes 113 (30.4) 119 (35.5) 1.26 (0.92–1.73) .146 0.97 (0.66–1.43) .876
GT + TT No 104 (28.0) 47 (14.0) 0.42 (0.29–0.62) <.001 1.13 (0.68–1.89) .641
GT + TT Yes 62 (16.7) 126 (37.6) 3.01 (2.12–4.28) <.001 1.50 (1.02–2.21) .038
Rs7396366 T2DM
GG No 173 (46.5) 122 (36.4) 0.66 (0.49–0.89) .007 0.68 (0.46–0.99) .042
GG Yes 33 (8.9) 40 (11.9) 1.39 (0.86–2.27) .216 0.91 (0.50–1.64) .748
GT + TT No 141 (37.9) 121 (36.1) 0.93 (0.68–1.26) .624 1.13 (0.77–1.65) .545
GT + TT Yes 25 (6.7) 52 (15.5) 2.55 (1.54–4.21) <.001 2.33 (1.24–4.38) .009
  1. Abbreviations: OR odds ratio, CI, confidence interval
  2. aLogistic regression model, adjusted by age, sex, hypertension, diabetes, smoking, BMI, and fasting plasma glucose