Table 1 Baseline characteristics
From: Real-world experience comparing two common left atrial appendage closure devices
Watchman™ (n = 154) | Amplatzer™ Amulet™ (n = 35) | p value* | OR (95% CI) | |
|---|---|---|---|---|
Male, n (%) | 105 (68.2) | 22 (62.9) | 0.55 | 1.27 (0.58–2.73) |
Age [years], mean ± SD | 75.2 ± 2.8 | 77.1 ± 9.7 | 0.27 | – |
CHA2DS2-VASc score, mean ± SD | 4.5 ± 0.1 | 4.0 ± 1.4 | 0.06 | – |
HAS-BLED score, mean ± SD | 3.6 ± 0.2 | 3.7 ± 1.0 | 0.12 | – |
HAS-BLED score ≥ 3, n (%) | 127 (82.5) | 33 (94.3) | 0.12 | 3.5 (0.79–15.52) |
Type of AF, each n (%) | ||||
Paroxysmal | 61 (39.6) | 17 (48.6) | 0.35 | 0.69 (0.31–1.55) |
Persistent | 41 (26.6) | 4 (11.4) | 0.08 | 3.72 (1.17–13.07) |
Permanent | 45 (29.2) | 14 (40.0) | 0.23 | 0.62 (0.27–1.42) |
Unknown | 7 (4.5) | 0 (0.0) | 0.35 | – |
Congestive heart failure, n (%) | 47 (30.5) | 8 (22.9) | 0.42 | 0.67 (0.28–1.60) |
Arterial hypertension, n (%) | 148 (96.1) | 34 (97.1) | 1.00 | 1.38 (0.16–11.84) |
Diabetes mellitus, n (%) | 52 (33.8) | 14 (40.0) | 0.56 | 1.31 (0.61–2.79) |
Prior cerebrovascular event, each n (%) | 44 (28.6) | 8 (22.9) | 0.54 | 0.74 (0.31–1.76) |
Vascular disease, n (%) | 98 (63.6) | 19 (54.3) | 0.34 | 0.68 (0.32–1.43) |
Chronic kidney disease, n (%) | 54 (35.1) | 12 (34.3) | 1.00 | 0.97 (0.44–2.10) |
Chronic liver disease, n (%) | 10 (6.5) | 4 (11.4) | 0.30 | 1.86 (0.54–6.32) |
Prior bleeding, n (%) | 100 (64.9) | 31 (88.6) | 0.008 | 4.19 (1.40–12.49) |
Bleeding localization, each n (%) | ||||
Intracranial | 28 (18.2) | 6 (17.1) | 1.00 | 1.07 (0.37–3.20) |
Gastrointestinal | 57 (37.0) | 20 (57.1) | 0.036 | 0.44 (0.73–1.00) |
Muscle | 3 (1.9) | 0 (0.0) | 1.00 | – |
Skin/mucosal | 4 (2.6) | 3 (8.6) | 0.12 | 0.28 (0.05–1.70) |
Other/unknown | 8 (5.2) | 2 (5.7) | 1.00 | 0.90 (0.16–6.49) |
Indication for LAAC, each n (%) | ||||
Prior bleeding | 93 (60.4) | 28 (80.0) | 0.032 | 0.38 (0.14–0.91) |
Drug intolerance | 25 (16.2) | 1 (2.9) | 0.05 | 6.59 (1.12–69.94) |
LAA thrombus despite OAC | 4 (2.6) | 1 (2.9) | 1.00 | 0.91 (0.14–11.39) |
Thromboembolic event despite OAC | 3 (1.9) | 2 (5.7) | 0.23 | 0.33 (0.06–1.92) |
Patient’s preference | 9 (5.8) | 0 (0.0) | 0.21 | – |
Other reason | 20 (13.0) | 3 (8.6) | 0.58 | 1.59 (0.47–5.32) |