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Table 3 Incidence of MI in the included studies by treatment allocation

From: A meta-analysis of the efficacy of allopurinol in reducing the incidence of myocardial infarction following coronary artery bypass grafting

Study ECG Enzyme Studies Imaging/Angiography/Autopsy Follow Up Incidence of MI: Total Incidence of MI: Allopurinol Incidence of MI: Control P value
Emerit et al. (1988) Ya Ya N NR 0 (0%) 0 (0%) 0 (0%) NR
Rashid et al. (1991)d Gross changesa AST, ALT > 2.5 μkat/Lb
LDH > 8 μkat /L
CK-MB > 1.7 μkat t/L
N NR 8 (8.9%) 0 (0%) 8 (17.8%) < 0.01
Coghlan et al. (1994) New Q waves N N During CABG only 3 (6.0%) 1 (4.0%) 2 (8.0%) NR
Taggart et al. (1994) New persistent Q waves (> 0.04 ms) or loss of > 25% of R waves in ≥2 leadsc N N 72 h post-CABG 0 (0%) 0 (0%) 0 (0%) NS
Castelli et al. (1995) Y Plasma CPK-MB > 50 IU/ml N NR 3 (9.1%) 1 (5.6%) 2 (13.3%) NS
Gimpel et al. (1995) New Q waves Plasma CK-MB > 15 U/L N 10 days post-CABG 2 (9.1%) 0 (0%) 2 (14.3%) NS
  1. ECG electrocardiogram, Y Yes, N No, NR not reported, AST aspartate transaminase, ALT alanine transaminase, LDH lactate dehydrogenase, CK-MB creatine kinase-MB, CABG coronary artery bypass graft, CPK-MB creatine phosphokinase-MB, NS not significant, NR not reported
  2. aNil further details provided
  3. bEspecially if AST elevated in the presence of normal ALT
  4. cIn isolation, minor ST-T wave changes or changes in conduction were not considered diagnostic of perioperative MI
  5. dDiagnostic criterion also considered the general condition of patient and signs of post-operative infarction (not specified)