A meta-analysis of the efficacy of allopurinol in reducing the incidence of myocardial infarction following coronary artery bypass grafting

Table 3 Incidence of MI in the included studies by treatment allocation

Study	ECG	Enzyme Studies	Imaging/Angiography/Autopsy	Follow Up	Incidence of MI: Total	Incidence of MI: Allopurinol	Incidence of MI: Control	P value
Emerit et al. (1988)	Y^a	Y^a	N	NR	0 (0%)	0 (0%)	0 (0%)	NR
Rashid et al. (1991)^d	Gross changes^a	AST, ALT > 2.5 μkat/L^b LDH > 8 μkat /L CK-MB > 1.7 μkat t/L	N	NR	8 (8.9%)	0 (0%)	8 (17.8%)	< 0.01
Coghlan et al. (1994)	New Q waves	N	N	During CABG only	3 (6.0%)	1 (4.0%)	2 (8.0%)	NR
Taggart et al. (1994)	New persistent Q waves (> 0.04 ms) or loss of > 25% of R waves in ≥2 leads^c	N	N	72 h post-CABG	0 (0%)	0 (0%)	0 (0%)	NS
Castelli et al. (1995)	Y	Plasma CPK-MB > 50 IU/ml	N	NR	3 (9.1%)	1 (5.6%)	2 (13.3%)	NS
Gimpel et al. (1995)	New Q waves	Plasma CK-MB > 15 U/L	N	10 days post-CABG	2 (9.1%)	0 (0%)	2 (14.3%)	NS

ECG electrocardiogram, Y Yes, N No, NR not reported, AST aspartate transaminase, ALT alanine transaminase, LDH lactate dehydrogenase, CK-MB creatine kinase-MB, CABG coronary artery bypass graft, CPK-MB creatine phosphokinase-MB, NS not significant, NR not reported
^aNil further details provided
^bEspecially if AST elevated in the presence of normal ALT
^cIn isolation, minor ST-T wave changes or changes in conduction were not considered diagnostic of perioperative MI
^dDiagnostic criterion also considered the general condition of patient and signs of post-operative infarction (not specified)

ISSN: 1471-2261