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Table 2 Characteristics of included studies

From: Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis

Study (Author, Year) Defnition of PAD Defnition of periodontitis Adjusted or matched factors NOS score
Aoyama et al. 2017 [22] PAD was diagnosed based on clinical symptoms, ABI, and angiographic fndings NR age, sex, smoking, hypertension, dyslipidemia and HbA1c levels 6
Çalapkorur et al. 2017 [34] Patients with ABI values of ≤0.90 were diagnosed as having PAD Periodontitis was defined as the presence of at least five teeth with one or more sites with a PD of ≥5 mm, a CAL of ≥2 mm, the presence of BOP and 30% radiographic bone loss age, gender, diabetes, hypertension and BMI 6
Ahn et al. 2016 [27] PAD was evaluated by using ABI lower than 1.0 The radiographic alveolar bone loss 4 mm at two or more interproximal sites, not on the same tooth age, sex, education level, tooth loss, smoking, drinking, central obesity 7
Soto-Barreras et al. 2013 [26] Patients with ABI values of ≤0.90 were diagnosed as having PAD The diagnosis of periodontitis was determined when the attachment loss was ≥4 mm in ≥30% of measured sites. age, sex, BMI,smoking, and diabetes mellitus 8
Chen et al. 2008 [30] PAD was diagnosed based on clinical symptoms, ABI, and angiographic fndings Participants who presented with at least one probing site with PD 4 mm or CAL 4 mm in each quadrant were defined as periodontitis patients Smoking, age, gender, and diabetes 7
Bloemenkamp et al. 2002 [33] PAD was angiographically confirmed when a stenotic lesion causing more than 50% reduction of the lumen was present in at least one major peripheral artery NR Smoking, age, gender, and diabetes 7
Mendez et al. 1998 [25] PAD was defined as one or more of the following: (1) intermittent claudication; (2) extracranial erebrovascular disease; (3) atherosclerosis (including aortic, renal, and mesenteric disease); and (4) arterial embolism and thrombosis. Periodontitis was considered present if the mean whole mouth alveolar bone loss was>20%. age, BMI, family history of heart disease, and smoking exposure 8
  1. ABI ankle brachial pressure index, PAD peripheral arterial disease, PD probing depth, CAL clinical attachment loss, BOP bleeding on probing, BMI body mass index, NR not report