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Table 3 Clinical outcomes

From: Relationship between high platelet reactivity on clopidogrel and long-term clinical outcomes after drug-eluting stents implantation (PAINT-DES): a prospective, propensity score-matched cohort study

 

Before propensity score matching

After propensity score matching

 

NPR on clopidogrel (n = 1360)

HPR on clopidogrel (n = 409)

P Value

NPR on clopidogrel (n = 395)

HPR on clopidogrel (n = 395)

P Value

Stent thrombosis

7 (0.5)

13 (3.2)

< 0.001

3 (0.8)

13 (3.3)

0.003

Definite/ probable Stent thrombosis

4 (0.3)

6 (1.5)

0.003

2 (0.5)

6 (1.5)

0.110

All cause death

18 (1.3)

21 (5.1)

< 0.001

7 (1.8)

21 (5.3)

< 0.001

 Cardiac death

6 (0.4)

10 (2.4)

0.001

2 (0.5)

10 (2.5)

0.004

MI

12 (0.9)

7 (1.7)

0.085

6 (1.5)

7 (1.8)

0.526

 STEMI

4 (0.3)

5 (1.2)

0.015

2 (0.5)

5 (1.3)

0.215

 NSTEMI

10 (0.7)

3 (0.7)

NS

5 (1.3)

3 (0.8)

0.734

Clinically driven TLR

40 (2.9)

26 (6.4)

< 0.001

24 (6.1)

26 (6.6)

0.111

Clinically driven TVR

43 (3.2)

32 (7.8)

< 0.001

25 (6.3)

32 (8.1)

0.019

Ischemic stroke

7 (0.5)

9 (2.2)

< 0.001

4 (1.0)

7 (1.8)

0.093

Bleeding (BARC≥2)

36 (2.6)

12 (2.9)

0.754

11 (2.8)

11 (2.8)

NS

MACCE

74 (5.4)

64 (15.6)

< 0.001

37 (9.4)

62 (15.7)

< 0.001

  1. Data are number of events (Kaplan-Meier estimated event rate), compared by the log-rank test
  2. NPR normal platelet reactivity, HPR high platelet reactivity, MI myocardial infarction, TLR target lesion revascularization, TVR target vessel revascularization, MACCE major adverse cardiovascular and cerebrovascular events