Pooled data | Ethiopia | Switzerland | ||||
---|---|---|---|---|---|---|
Benefit or harm outcomes related to statins | Coefficient (95% CI) Pairs = 34,320 | Preference weight (95% CI) | Coefficient (95% CI (Pairs = 15,600) | Preference weight (95% CI) | Coefficient (95% CI) (Pairs = 18,720) | Preference weight (95% CI) |
Severe stroke | 6.1 (5.8–6.4) | 1.00 (0.997–1.00)b | 5.3 (4.9–5.7) | 0.999 (0.996–1.00) b | 7.4 (6.9–7.9) | 1.00 (0.997–1.00)b |
Severe MI | 4.6 (4.3–4.8) | 0.913 (0.889–0.942) | 4.0 (3.7–4.3) | 0.903 (0.864–0.941) | 5.6 (5.2–6.0) | 0.869 (0.848–0.921) |
Cancera | 3.9 (3.7–4.1) | 0.846 (0.829–0.855) | 3.6 (3.3–3.9) | 0.848 (0.821–0.862) | 4.4 (4.0–4.7) | 0.859 (0.843–0.880) |
Moderate stroke | 3.1 (2.9–3.3) | 0.735 (0.671–0.802) | 2.7 (2.4–3.0) | 0.686 (0.600–0.783) | 3.8 (3.4–4.6) | 0.766 (0.644–0.818) |
Moderate MI | 2.6 (2.4–2.8) | 0.664 (0.611–0.715) | 2.1 (1.8–2.4) | 0.589 (0.517–0.661) | 3.2 (2.9–3.5) | 0.645 (0.553–0.692) |
Heart failure | 2.3 (2.1–2.5) | 0.591 (0.534–0.647) | 2.5 (2.3–2.8) | 0.642 (0.593–0.775) | 2.2 (1.9–2.5) | 0.576 (0.513–0.655) |
Type 2 idabetesa | 1.7 (1.5–1.9) | 0.470 (0.452–0.501) | 1.9 (1.6–2.2) | 0.557 (0.537–0.608) | 1.5 (1.3–1.8) | 0.378 (0.347–0.424) |
Liver injurya | 1.4 (1.2–1.5) | 0.431 (0.345–0.475) | 1.3 (1.0–1.5) | 0.382 (0.300–0.489) | 1.4 (1.2–1.7) | 0.461 (0.350–0.531) |
Unstable angina | 1.0 (0.8–1.2) | 0.236 (0.205–0.257) | 0.8 (0.6–1.1) | 0.255 (0.230–0.302) | 1.3 (1.0–1.5) | 0.285 (0.247–0.323) |
Acute kidney failurea | 0.9 (0.7–1.1) | 0.236 (0.215–0.252) | 1.2 (0.9–1.4) | 0.283 (0.239–0.296) | 0.7 (0.4–0.9) | 0.262 (0.242–0.293) |
Myopathya | 0.6 (0.4–0.8) | 0.230 (0.228–0.238) | 0.6 (0.4–0.8) | 0.256 (0.254–0.258) | 0.6 (0.4–0.8) | 0.255 (0.253–0.256) |
Nausea/headachea | 0.2 (0.0–0.4) | 0.060 (0.034–0.094) | 0.2 (−0.1–0.5) | 0.093 (0.060–0.139) | 0.2 (0.0–0.5) | 0.065 (0.035–0.105) |
Treatment discontinuationa,c | 0.0 | 0.090 (0.023–0.123) | 0.00 | 0.020 (0.00–0.090) | 0.0 | 0.085 (0.002–0.141) |