Fig. 2
From: SHP2 inhibitor PHPS1 protects against atherosclerosis by inhibiting smooth muscle cell proliferation
Effect of PHPS1 on atherosclerotic lesion size in Ldlr−/− mice. The lesion volume/vessel volume ratio at the aortic root was analyzed by Movat staining. The number of smooth muscle cells in the plaques from the aortic root was determined by immunohistochemistry. PHPS1 treatment significantly reduced the atherosclerotic plaque area and inhibited the formation of atherosclerotic plaques. Compared with the intima in the other two groups, the intima was mildly thickened, the smooth muscle cells were arranged neatly, and smooth muscle cell proliferation was decreased in the AS+PHPS1 group. PHPS1 treatment inhibited the proliferation of vascular smooth muscle cells. Data are presented as the mean ± SE (n = 10 per group). *p < 0.05 vs. the AS group