Table 4 Patients ≤65 years of age
Treatment Patterns (ACEI, ARB, or BB)a | Treatment Patterns (Diuretic)a | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Increase (n = 57,100)b | No Changes (n = 754,371) | Decrease (n = 51,608) | Rate Ratio for Treatment Increase | Rate Ratio for Treatment Decrease | No to Yes (n = 30,326) | No Changes (n = 802,586) | Yes to No (n = 32,273) | Rate Ratio for Treatment Increase | Rate Ratio for Treatment Decrease | |
NYHA class change, %c | ||||||||||
Increase (n = 6604) | 8.2 | 83.4 | 8.0 | 1.3 | 1.4 | 5.9 | 89.8 | 4.2 | 2.0 | 1.1 |
No changes (n = 247.910) | 6.2 | 87.6 | 5.9 | – | – | 3.0 | 93.3 | 3.7 | – | – |
Decrease (n = 7455) | 8.3 | 84.2 | 7.2 | 1.3 | 1.2 | 4.5 | 90.7 | 4.8 | 1.5 | 1.3 |
Dyspnea change, %c | ||||||||||
No to yes (n = 25.590) | 14.0 | 80.3 | 5.3 | 2.3 | 1.0 | 7.8 | 89.1 | 3.1 | 2.4 | 0.9 |
No changes n = 665,509) | 6.2 | 88.2 | 5.3 | – | – | 3.3 | 93.3 | 3.4 | – | – |
Yes to no (n = 17,044) | 5.0 | 77.0 | 17.7 | 0.8 | 3.3 | 3.0 | 87.5 | 9.6 | 0.9 | 2.8 |
Orthopnea change, %c | ||||||||||
No to yes (n = 12,903) | 12.3 | 82.4 | 4.9 | 1.9 | 0.9 | 6.7 | 90.4 | 2.9 | 1.9 | 0.8 |
No changes (n = 729,881) | 6.5 | 87.5 | 5.7 | – | – | 3.5 | 92.9 | 3.7 | – | – |
Yes to no (n = 9829) | 4.8 | 81.1 | 13.8 | 0.7 | 2.4 | 2.9 | 90.1 | 7.0 | 0.8 | 1.9 |
Changes in signs, %c,d | ||||||||||
Increase (n = 25,689) | 12.8 | 81.1 | 5.7 | 2.0 | 1.0 | 7.9 | 88.7 | 3.4 | 2.4 | 1.0 |
No changes (n = 428,162) | 6.4 | 87.9 | 5.5 | – | – | 3.3 | 93.2 | 3.5 | – | – |
Decrease (n = 21,623) | 6.3 | 81.0 | 12.2 | 1.0 | 2.2 | 3.2 | 89.1 | 7.7 | 1.0 | 2.2 |