Table 1 Clinical and anthropometric characteristics of carotid stenosis patients subdivided into asymptomatic/symptomatic and patients without/with coronary artery disease (CAD)
From: Increased circulating chemerin in patients with advanced carotid stenosis
controls | patients | patients | patients | ||||||
|---|---|---|---|---|---|---|---|---|---|
p-value | asymptomatic | symptomatic | p-value | no CAD | CAD | p-value | |||
number | 163 | 178 | 93 | 85 | 128 | 50 | |||
age | 65.2 ± 0.7 | 66.9 ± 0.6 | 0.058 | 68.0 [62.5–73.5] | 68.0 [59.0–73.0] | 0.924 | 67.0 [59.0–71.8] | 71.5 [66.0–75.2] | 0.001 |
gender (m: w) | 105: 58 | 121: 57 | 0.487 | 66: 27 | 55: 30 | 0.371 | 82: 46 | 39: 11 | 0.073 |
BMI (kg/m2) | 29.1 [25.7–31.5] | 26.6 [24.5–29.3] | < 0.0001 | 26.9 [24.8–28.9] | 26.2 [23.9–30.1] | 0.789 | 26.6 [24.2–29.0] | 27.1 [25.1–30.0] | 0.286 |
Stenosis (%) | nd | 85.0 [85.0–90.0] | 85.0 [80.0–90.0] | 85.0 [85.0–90.0] | 0.668 | 85.0 [85.0–90.0] | 85.0 [80.0–90.0] | 0.690 | |
(Ex) smoker (%) | nd | 69.9 | 69.7 | 70.2 | 0.934 | 74.4 | 63.3 | 0.229 | |
hypertension (%) | nd | 93.3 | 95.7 | 90.6 | 0.174 | 91.4 | 98.0 | 0.115 | |
systolic blood pressure (mmHg) | nd | 140.0 [130.0–160.0] | 140.0 [130.0–160.0] | 140.0 [130.0–156.3] | 0.617 | 145.0 [130.0–160.0] | 140.0 [121.8–150.0] | 0.073 | |
diastolic blood pressure (mmHg) | nd | 80.0 [70.00–90.0] | 80.0 [70.0–90.0] | 80.0 [70.0–90.0] | 0.570 | 80.0 [70.0–90.0] | 80.0 [70.0–85.0] | 0.461 | |
T2DM (%) | 49.1 | 40.4 | 0.111 | 38.7 | 42.4 | 0.621 | 33.6 | 58.0 | 0.003 |
fasting glucose (mmol/l) | 5.6 [4.9–6.8] | 5.9 [5.1–7.1] | 0.166 | 5.7 [5.1–7.1] | 5.9 [5.1–7.1] | 0.709 | 5.7 |5.1–7.0| | 6.0 [5.1–7.8] | 0.482 |
HbA1c (%) | 5.8 [5.4–6.3] | 5.9 [5.5–6.5] | 0.161 | 6.0 [5.5–6.6] | 5.9 [5.5–7.1] | 0.566 | 5.8 [5.4–6.4] | 6.2 [5.8–7.8] | 0.010 |
total cholesterol (mmol/l) | 5.2 ± 0.1 | 4.9 ± 0.1 | 0.009 | 5.1 ± 0.1 | 4.6 ± 0.1 | 0.006 | 4.9 ± 0.1 | 4.7 ± 0.1 | 0.187 |
LDL cholesterol (mmol/l) | 3.2 [2.8–3.8] | 2.8 [2.2–3.6] | 0.001 | 2.9 [2.3–3.9] | 2.5 [2.0–3.3] | 0.047 | 2.9 [2.2–3.8] | 2.6 [2.2–3.2] | 0.245 |
HDL cholesterol (mmol/l) | 1.4 [1.1–1.7] | 1.2 [1.0–1.5] | 0.005 | 1.3 ± 0.05 | 1.2 ± 0.04 | 0.006 | 1.2 [1.0–1.5] | 1.2 [0.9–1.5] | 0.907 |
triglyceride (mmol/l) | 1.5 [1.1–2.2] | 1.7 [1.2–2.6] | 0.042 | 1.7 [1.2–2.7] | 1.7 [1.2–2.6] | 0.791 | 1.8 [1.2–2.6] | 1.5 [1.1–2.8] | 0.691 |
Leukocyte blood count (exp9/l) | 6.7 [5.6–8.4] | 7.6 [6.1–8.9] | 0.001 | 7.5 [6.0–9.0] | 7.8 [6.3–8.8] | 0.382 | 7.7 [6.3–9.3] | 7.2 [5.8–8.5] | 0.068 |
CRP (mg/l) | 2.5 [1.3–5.1] | 3.5 [1.6–8.0] | 0.010 | 2.5 [1.4–5.6] | 4.5 [1.8–9.5] | 0.027 | 3.2 [1.5–8.0] | 3.9 [1.6–7.9] | 0.863 |
TNF-α (pg/ml) | nd | 2.7 [2.2–4.9] | 3.1 [2.5–4.4] | 2.6 [2.1–3.9] | 0.191 | 2.6 [2.1–4.7] | 3.0 [2.2–3.9] | 0.983 | |
chemerin (ng/ml) | 185.7 [151.8–208.2] | 229.9 [200.6–282.0] | < 0.001 | 223.2 [197.9–277.7] | 240.2 [201.6–286.8] | 0.498 | 223.2 [193.3–272.2] | 255.9 [207.9–327.2] | 0.002 |
statine treatment (%) | nd | 63.5 | 58.1 | 69.4 | 0.116 | 60.2 | 72.0 | 0.140 | |
antithrombotic treatment (%) | nd | 88.8 | 89.2 | 88.2 | 0.831 | 89.8 | 86.0 | 0.466 |