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Table 1 Clinical and anthropometric characteristics of carotid stenosis patients subdivided into asymptomatic/symptomatic and patients without/with coronary artery disease (CAD)

From: Increased circulating chemerin in patients with advanced carotid stenosis

  controls patients   patients    patients   
    p-value asymptomatic symptomatic p-value no CAD CAD p-value
number 163 178   93 85   128 50  
age 65.2 ± 0.7 66.9 ± 0.6 0.058 68.0 [62.5–73.5] 68.0 [59.0–73.0] 0.924 67.0 [59.0–71.8] 71.5 [66.0–75.2] 0.001
gender (m: w) 105: 58 121: 57 0.487 66: 27 55: 30 0.371 82: 46 39: 11 0.073
BMI (kg/m2) 29.1 [25.7–31.5] 26.6 [24.5–29.3] < 0.0001 26.9 [24.8–28.9] 26.2 [23.9–30.1] 0.789 26.6 [24.2–29.0] 27.1 [25.1–30.0] 0.286
Stenosis (%) nd 85.0 [85.0–90.0]   85.0 [80.0–90.0] 85.0 [85.0–90.0] 0.668 85.0 [85.0–90.0] 85.0 [80.0–90.0] 0.690
(Ex) smoker (%) nd 69.9   69.7 70.2 0.934 74.4 63.3 0.229
hypertension (%) nd 93.3   95.7 90.6 0.174 91.4 98.0 0.115
systolic blood pressure (mmHg) nd 140.0 [130.0–160.0]   140.0 [130.0–160.0] 140.0 [130.0–156.3] 0.617 145.0 [130.0–160.0] 140.0 [121.8–150.0] 0.073
diastolic blood pressure (mmHg) nd 80.0 [70.00–90.0]   80.0 [70.0–90.0] 80.0 [70.0–90.0] 0.570 80.0 [70.0–90.0] 80.0 [70.0–85.0] 0.461
T2DM (%) 49.1 40.4 0.111 38.7 42.4 0.621 33.6 58.0 0.003
fasting glucose (mmol/l) 5.6 [4.9–6.8] 5.9 [5.1–7.1] 0.166 5.7 [5.1–7.1] 5.9 [5.1–7.1] 0.709 5.7 |5.1–7.0| 6.0 [5.1–7.8] 0.482
HbA1c (%) 5.8 [5.4–6.3] 5.9 [5.5–6.5] 0.161 6.0 [5.5–6.6] 5.9 [5.5–7.1] 0.566 5.8 [5.4–6.4] 6.2 [5.8–7.8] 0.010
total cholesterol (mmol/l) 5.2 ± 0.1 4.9 ± 0.1 0.009 5.1 ± 0.1 4.6 ± 0.1 0.006 4.9 ± 0.1 4.7 ± 0.1 0.187
LDL cholesterol (mmol/l) 3.2 [2.8–3.8] 2.8 [2.2–3.6] 0.001 2.9 [2.3–3.9] 2.5 [2.0–3.3] 0.047 2.9 [2.2–3.8] 2.6 [2.2–3.2] 0.245
HDL cholesterol (mmol/l) 1.4 [1.1–1.7] 1.2 [1.0–1.5] 0.005 1.3 ± 0.05 1.2 ± 0.04 0.006 1.2 [1.0–1.5] 1.2 [0.9–1.5] 0.907
triglyceride (mmol/l) 1.5 [1.1–2.2] 1.7 [1.2–2.6] 0.042 1.7 [1.2–2.7] 1.7 [1.2–2.6] 0.791 1.8 [1.2–2.6] 1.5 [1.1–2.8] 0.691
Leukocyte blood count (exp9/l) 6.7 [5.6–8.4] 7.6 [6.1–8.9] 0.001 7.5 [6.0–9.0] 7.8 [6.3–8.8] 0.382 7.7 [6.3–9.3] 7.2 [5.8–8.5] 0.068
CRP (mg/l) 2.5 [1.3–5.1] 3.5 [1.6–8.0] 0.010 2.5 [1.4–5.6] 4.5 [1.8–9.5] 0.027 3.2 [1.5–8.0] 3.9 [1.6–7.9] 0.863
TNF-α (pg/ml) nd 2.7 [2.2–4.9]   3.1 [2.5–4.4] 2.6 [2.1–3.9] 0.191 2.6 [2.1–4.7] 3.0 [2.2–3.9] 0.983
chemerin (ng/ml) 185.7 [151.8–208.2] 229.9 [200.6–282.0] < 0.001 223.2 [197.9–277.7] 240.2 [201.6–286.8] 0.498 223.2 [193.3–272.2] 255.9 [207.9–327.2] 0.002
statine treatment (%) nd 63.5   58.1 69.4 0.116 60.2 72.0 0.140
antithrombotic treatment (%) nd 88.8   89.2 88.2 0.831 89.8 86.0 0.466
  1. Mean ± SEM, for non-normally distributed parameters median [interquartile range] are given; significant differences are in bold
  2. BMI body mass index, CAD coronary artery disease, CRP C-reactive protein, HDL high density lipoprotein, LDL low density lipoprotein, T2DM type 2 diabetes mellitus, TNF-α tumor-necrosis factor-α