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Fig. 4 | BMC Cardiovascular Disorders

Fig. 4

From: Comprehensive microRNA profiling reveals potential augmentation of the IL1 pathway in rheumatic heart valve disease

Fig. 4

Target prediction and verification of hsa-mir-205-3p and hsa-mir-3909. a The 3’UTR of IL-1β and hsa-mir-205-3p were aligned, and the 3’UTR of IL1R1 and hsa-mir-3909 were aligned. The complementary sequences were marked. b and c Luciferase reporter plasmids containing the IL-1β or IL1R1 3’-UTR were co-transfected into HEK293T cells with hsa-mir-205p, hsa-3909 or control miRNA. Twenty-four hours after transfection, the luciferase activity was measured. The normalized luciferase activity in the control group was set to 1. Ns P > 0.05; ** P < 0.01 by the Student t-test

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