TY - JOUR AU - Fan, Zhixin AU - Gao, Yufei AU - Huang, Zhiwei AU - Xue, Fenghua AU - Wu, Shujing AU - Yang, Jing AU - Zhu, Liqun AU - Fu, Lu PY - 2018 DA - 2018/02/13 TI - Protective effect of hydrogen-rich saline on pressure overload-induced cardiac hypertrophyin rats: possible role of JAK-STAT signaling JO - BMC Cardiovascular Disorders SP - 32 VL - 18 IS - 1 AB - Molecular hydrogen has been shown to have antioxidant effect and have been used to prevent oxidative stress-related diseases. The goal of this study was to explore if hydrogen-rich saline (HRS) plays a cardioprotective effect on abdominal aortic constriction (AAC) induced cardiac hypertrophy in rats. 60adult Sprague–Dawley rats received surgically the AAC for 6-week. After the surgery, the rats were randomly divided into 4 groups (15 for each):1: sham-operated (sham); 2: AAC-model; 3: AAC + Low HRS (LHRS); and 4: AAC + High HRS (HHRS). The rats in sham and AAC-model groups were treated with normal saline intraperitoneally, while rats in LHRS and HHRS groups were intraperitoneally treated with 3 or 6 mL/kg HRS daily, respectively, for 6-week. SN - 1471-2261 UR - https://doi.org/10.1186/s12872-018-0773-9 DO - 10.1186/s12872-018-0773-9 ID - Fan2018 ER -