Genetic models | Subgroup | Test of association | N | Sample size | Heterogeneity | ||||
---|---|---|---|---|---|---|---|---|---|
OR (95% CIs) | z | P value | case | control | I2 | P value | |||
allele (A vs. G) | overall | 0.95 (0.87, 1.04) | 1.05 | 0.295 | 17 | 10,213 | 8033 | 69.9% | < 0.001 |
Asian | 0.95 (0.87, 1.04) | 1.16 | 0.246 | 15 | 6352 | 5867 | 73.0% | < 0.001 | |
CAD | 0.78 (0.68, 0.90) | 3.40 | 0.001 | 5 | 1934 | 1609 | 38.9% | 0.162 | |
IS | 0.93 (0.74, 1.18) | 0.58 | 0.564 | 4 | 1515 | 1545 | 78.0% | 0.003 | |
hypertension | 1.07 (0.99, 1.15) | 1.69 | 0.090 | 8 | 6764 | 4879 | 21.8% | 0.256 | |
population-based | 0.92 (0.81, 1.05) | 1.26 | 0.209 | 12 | 5203 | 4584 | 73.4% | < 0.001 | |
homozygote (AA vs. GG) | overall | 0.94 (0.76, 1.16) | 0.58 | 0.561 | 17 | 10,213 | 8033 | 64.5% | < 0.001 |
Asian | 0.90 (0.71, 1.16) | 0.81 | 0.418 | 15 | 6352 | 5867 | 67.9% | < 0.001 | |
CAD | 0.55 (0.39, 0.77) | 3.44 | 0.001 | 5 | 1934 | 1609 | 24.9% | 0.255 | |
IS | 0.90 (0.56, 1.44) | 0.45 | 0.651 | 4 | 1515 | 1545 | 73.9% | 0.009 | |
hypertension | 0.90 (1.02, 1.37) | 2.29 | 0.022 | 8 | 6764 | 4879 | 0.0% | 0.525 | |
population-based | 0.91 (0.70, 1.19) | 0.70 | 0.487 | 12 | 5203 | 4584 | 64.3% | 0.001 | |
heterozygote (GA vs. GG) | overall | 0.95 (0.89, 1.01) | 1.69 | 0.092 | 17 | 10,213 | 8033 | 43.9% | 0.027 |
Asian | 0.92 (0.85, 1.00) | 2.06 | 0.039 | 15 | 6352 | 5867 | 48.3% | 0.019 | |
CAD | 0.80 (0.69, 0.92) | 3.14 | 0.002 | 5 | 1934 | 1609 | 37.2% | 0.173 | |
IS | 0.94 (0.80, 1.09) | 0.84 | 0.400 | 4 | 1515 | 1545 | 47.8% | 0.125 | |
hypertension | 1.00 (0.93, 1.09) | 0.09 | 0.927 | 8 | 6764 | 4879 | 19.2% | 0.278 | |
population-based | 0.91 (0.83, 0.99) | 2.15 | 0.032 | 12 | 5203 | 4584 | 57.8% | 0.006 | |
dominant (GA + AA vs. GG) | overall | 0.93 (0.83, 1.03) | 1.46 | 0.145 | 17 | 10,213 | 8033 | 59.3% | 0.001 |
Asian | 0.91 (0.80, 1.03) | 1.49 | 0.135 | 15 | 6352 | 5867 | 62.9% | 0.001 | |
CAD | 0.77 (0.64, 0.92) | 2.83 | 0.005 | 5 | 1934 | 1609 | 43.3% | 0.133 | |
IS | 0.93 (0.71, 1.21) | 0.57 | 0.572 | 4 | 1515 | 1545 | 69.4% | 0.020 | |
hypertension | 1.03 (0.95, 1.12) | 0.77 | 0.442 | 8 | 6764 | 4879 | 6.0% | 0.384 | |
population-based | 0.89 (0.77, 1.03) | 1.52 | 0.130 | 12 | 5203 | 4584 | 68.5% | < 0.001 | |
recessive (AA vs. GG + GA) | overall | 0.98 (0.82, 1.18) | 0.22 | 0.827 | 17 | 10,213 | 8033 | 58.7% | 0.001 |
Asian | 0.95 (0.77, 1.17) | 0.49 | 0.625 | 15 | 6352 | 5867 | 62.5% | 0.001 | |
CAD | 0.60 (0.44, 0.83) | 3.06 | 0.002 | 5 | 1934 | 1609 | 19.2% | 0.293 | |
IS | 0.93 (0.65, 1.33) | 0.40 | 0.692 | 4 | 1515 | 1545 | 58.8% | 0.064 | |
hypertension | 1.22 (1.05, 1.43) | 2.52 | 0.012 | 8 | 6764 | 4879 | 12.5% | 0.333 | |
population-based | 0.96 (0.77, 1.19) | 0.39 | 0.694 | 12 | 5203 | 4584 | 50.5% | 0.023 |