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Table 2 Meta-analysis of CYP4AF2 rs2108622 G/A polymorphism

From: Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases

Genetic models Subgroup Test of association N Sample size Heterogeneity
OR (95% CIs) z P value case control I2 P value
allele (A vs. G) overall 0.95 (0.87, 1.04) 1.05 0.295 17 10,213 8033 69.9% < 0.001
Asian 0.95 (0.87, 1.04) 1.16 0.246 15 6352 5867 73.0% < 0.001
CAD 0.78 (0.68, 0.90) 3.40 0.001 5 1934 1609 38.9% 0.162
IS 0.93 (0.74, 1.18) 0.58 0.564 4 1515 1545 78.0% 0.003
hypertension 1.07 (0.99, 1.15) 1.69 0.090 8 6764 4879 21.8% 0.256
population-based 0.92 (0.81, 1.05) 1.26 0.209 12 5203 4584 73.4% < 0.001
homozygote (AA vs. GG) overall 0.94 (0.76, 1.16) 0.58 0.561 17 10,213 8033 64.5% < 0.001
Asian 0.90 (0.71, 1.16) 0.81 0.418 15 6352 5867 67.9% < 0.001
CAD 0.55 (0.39, 0.77) 3.44 0.001 5 1934 1609 24.9% 0.255
IS 0.90 (0.56, 1.44) 0.45 0.651 4 1515 1545 73.9% 0.009
hypertension 0.90 (1.02, 1.37) 2.29 0.022 8 6764 4879 0.0% 0.525
population-based 0.91 (0.70, 1.19) 0.70 0.487 12 5203 4584 64.3% 0.001
heterozygote (GA vs. GG) overall 0.95 (0.89, 1.01) 1.69 0.092 17 10,213 8033 43.9% 0.027
Asian 0.92 (0.85, 1.00) 2.06 0.039 15 6352 5867 48.3% 0.019
CAD 0.80 (0.69, 0.92) 3.14 0.002 5 1934 1609 37.2% 0.173
IS 0.94 (0.80, 1.09) 0.84 0.400 4 1515 1545 47.8% 0.125
hypertension 1.00 (0.93, 1.09) 0.09 0.927 8 6764 4879 19.2% 0.278
population-based 0.91 (0.83, 0.99) 2.15 0.032 12 5203 4584 57.8% 0.006
dominant (GA + AA vs. GG) overall 0.93 (0.83, 1.03) 1.46 0.145 17 10,213 8033 59.3% 0.001
Asian 0.91 (0.80, 1.03) 1.49 0.135 15 6352 5867 62.9% 0.001
CAD 0.77 (0.64, 0.92) 2.83 0.005 5 1934 1609 43.3% 0.133
IS 0.93 (0.71, 1.21) 0.57 0.572 4 1515 1545 69.4% 0.020
hypertension 1.03 (0.95, 1.12) 0.77 0.442 8 6764 4879 6.0% 0.384
population-based 0.89 (0.77, 1.03) 1.52 0.130 12 5203 4584 68.5% < 0.001
recessive (AA vs. GG + GA) overall 0.98 (0.82, 1.18) 0.22 0.827 17 10,213 8033 58.7% 0.001
Asian 0.95 (0.77, 1.17) 0.49 0.625 15 6352 5867 62.5% 0.001
CAD 0.60 (0.44, 0.83) 3.06 0.002 5 1934 1609 19.2% 0.293
IS 0.93 (0.65, 1.33) 0.40 0.692 4 1515 1545 58.8% 0.064
hypertension 1.22 (1.05, 1.43) 2.52 0.012 8 6764 4879 12.5% 0.333
population-based 0.96 (0.77, 1.19) 0.39 0.694 12 5203 4584 50.5% 0.023
  1. OR odds ratio, CIs confidence intervals, CAD coronary artery disease, IS ischemic stroke, N number of case-control studies