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Table 2 Meta-analysis of CYP4AF2 rs2108622 G/A polymorphism

From: Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases

Genetic models

Subgroup

Test of association

N

Sample size

Heterogeneity

OR (95% CIs)

z

P value

case

control

I2

P value

allele (A vs. G)

overall

0.95 (0.87, 1.04)

1.05

0.295

17

10,213

8033

69.9%

< 0.001

Asian

0.95 (0.87, 1.04)

1.16

0.246

15

6352

5867

73.0%

< 0.001

CAD

0.78 (0.68, 0.90)

3.40

0.001

5

1934

1609

38.9%

0.162

IS

0.93 (0.74, 1.18)

0.58

0.564

4

1515

1545

78.0%

0.003

hypertension

1.07 (0.99, 1.15)

1.69

0.090

8

6764

4879

21.8%

0.256

population-based

0.92 (0.81, 1.05)

1.26

0.209

12

5203

4584

73.4%

< 0.001

homozygote (AA vs. GG)

overall

0.94 (0.76, 1.16)

0.58

0.561

17

10,213

8033

64.5%

< 0.001

Asian

0.90 (0.71, 1.16)

0.81

0.418

15

6352

5867

67.9%

< 0.001

CAD

0.55 (0.39, 0.77)

3.44

0.001

5

1934

1609

24.9%

0.255

IS

0.90 (0.56, 1.44)

0.45

0.651

4

1515

1545

73.9%

0.009

hypertension

0.90 (1.02, 1.37)

2.29

0.022

8

6764

4879

0.0%

0.525

population-based

0.91 (0.70, 1.19)

0.70

0.487

12

5203

4584

64.3%

0.001

heterozygote (GA vs. GG)

overall

0.95 (0.89, 1.01)

1.69

0.092

17

10,213

8033

43.9%

0.027

Asian

0.92 (0.85, 1.00)

2.06

0.039

15

6352

5867

48.3%

0.019

CAD

0.80 (0.69, 0.92)

3.14

0.002

5

1934

1609

37.2%

0.173

IS

0.94 (0.80, 1.09)

0.84

0.400

4

1515

1545

47.8%

0.125

hypertension

1.00 (0.93, 1.09)

0.09

0.927

8

6764

4879

19.2%

0.278

population-based

0.91 (0.83, 0.99)

2.15

0.032

12

5203

4584

57.8%

0.006

dominant (GA + AA vs. GG)

overall

0.93 (0.83, 1.03)

1.46

0.145

17

10,213

8033

59.3%

0.001

Asian

0.91 (0.80, 1.03)

1.49

0.135

15

6352

5867

62.9%

0.001

CAD

0.77 (0.64, 0.92)

2.83

0.005

5

1934

1609

43.3%

0.133

IS

0.93 (0.71, 1.21)

0.57

0.572

4

1515

1545

69.4%

0.020

hypertension

1.03 (0.95, 1.12)

0.77

0.442

8

6764

4879

6.0%

0.384

population-based

0.89 (0.77, 1.03)

1.52

0.130

12

5203

4584

68.5%

< 0.001

recessive (AA vs. GG + GA)

overall

0.98 (0.82, 1.18)

0.22

0.827

17

10,213

8033

58.7%

0.001

Asian

0.95 (0.77, 1.17)

0.49

0.625

15

6352

5867

62.5%

0.001

CAD

0.60 (0.44, 0.83)

3.06

0.002

5

1934

1609

19.2%

0.293

IS

0.93 (0.65, 1.33)

0.40

0.692

4

1515

1545

58.8%

0.064

hypertension

1.22 (1.05, 1.43)

2.52

0.012

8

6764

4879

12.5%

0.333

population-based

0.96 (0.77, 1.19)

0.39

0.694

12

5203

4584

50.5%

0.023

  1. OR odds ratio, CIs confidence intervals, CAD coronary artery disease, IS ischemic stroke, N number of case-control studies