Table 3 Prevalence of cardiovascular autonomic neuropathy and parameters for the evaluation of cardiovascular parasympathetic and sympathetic nervous system in patients with congenital generalized lipodistrophy, type 1 diabetes and healthy individuals
Variables | CGL (n = 10) | Type 1 diabetes (n = 20) | Healthy (n = 20) | p1 | p2 | p3 |
|---|---|---|---|---|---|---|
Clinical CAN % (n) | 40 (4) | 5 (1) | 0 | 0.031 | 0.008 | 1.000 |
Incipient CAN % (n) | 10 (1) | 15 (3) | 0 | 1.000 | 0.333 | 0.115 |
CAN % (n) | 50 (5) | 20 (4) | 0 | 0.115 | 0.002 | 0.106 |
Altered 30/15 coefficient % (n) | 40 (4) | 15 (3) | 0 | 0.181 | 0.008 | 0.231 |
Altered Valsalva coefficient % (n) | 10 (1) | 0 | 0 | 0.333 | 0.333 | 1.000 |
Altered E/I coefficient % (n) | 30 (3) | 5 (1) | 0 | 0.095 | 0.030 | 1.000 |
Postural hypotension % (n) | 10 (1) | 0 | 0 | 0.333 | 0.333 | 1.000 |
Parasympathetic System | ||||||
30/15 coefficient | 1.19 (0.98; 1.59) | 1.34 (1.04; 1.68) | 1.55 (2.26; 2.02) | 0.064 | 0.001 | 0.001 |
E/I coefficient | 1.33 (1.09; 1.57) | 1.52 (1.14; 2.01) | 1.60 (1.23; 2.23) | 0.004 | 0.001 | 0.323 |
Component of high frequency (Hz) | 627 (55; 1840) | 1447 (182; 8374) | 2993 (270; 9969) | 0.019 | 0.001 | 0.064 |
SDNN | 64 (22; 169) | 60 (25; 124) | 82 (36; 163) | 0.965 | 0.113 | 0.039 |
RMSSD | 57 (12; 237) | 52 (17; 170) | 85 (18; 180) | 0.877 | 0.252 | 0.069 |
Sympathetic system | ||||||
Reduction in SBP >10 mmHg % (n) | 30 (3) | 10 (2) | 5 (1) | 0.300 | 0.095 | 1.000 |
Reduction in SBP > 20 mmHg % (n) | 10 (1) | 0 | 0 | 0.333 | 0.333 | 1.000 |
Component of very low frequency (Hz) | 383 (88; 4250) | 1077 (392; 5857) | 1988 (688; 18,341) | 0.017 | 0.002 | 0.026 |
Parasympathetic and sympathetic systems | ||||||
Valsalva coefficient | 1.54 (1.15; 2.34) | 1.70 (1.24; 2.52) | 1.74 (1.50; 2.42) | 0.166 | 0.039 | 0.297 |
Component of low frequency (Hz) | 329 (139; 2525) | 972 (181; 3109) | 1916 (343; 5580) | 0.033 | 0.001 | 0.017 |
Total spectrum amplitude (Hz) | 1582 (501;9691) | 4482 (755; 12,854) | 7125 (1853; 24,788) | 0.019 | 0.000 | 0.013 |
LF/HF ratio | 1.21 (0.12; 3.70) | 0.67 (0.19; 1.99) | 0.58 (0.26; 1.70) | 0.235 | 0.454 | 0.892 |