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Table 1 Study population

From: Retinal capillary rarefaction in patients with untreated mild-moderate hypertension

 

Short time hypertensive patients (n = 70)

Long time hypertensive patients (n = 64)

Healthy control subjects (n = 55)

ANOVA results p-value

Clinical characteristics

Age (years)

52 ± 9.3

51 ± 13

53 ± 13

p = 0.585

BMI (kg/m2)

28.3 (25–31)

27.8 (26–30)

25.3 (23–29)

p = 0.011

Sex (male/female)

46/24

53/11

19/36

p < 0.001

Systolic Office BP (mmHg)

146 ± 12

147 ± 11

124 ± 12

p < 0.001

Diastolic Office BP (mmHg)

90 ± 8.6

89 ± 9.1

79 ± 9.1

p < 0.001

HR (bpm)

73 ± 8.6

73 ± 7.9

70 ± 13

p = 0.739

Systolic 24 h Ambulatory BP (mmHg)

142 ± 10.2

148 ± 9.7

120 ± 9.6

p < 0.001

Diastolic 24 h Ambulatory BP (mmHg)

89 ± 9.4

92 ± 9.9

75 ± 4.1

p < 0.001

Serum creatinine (mmol/L)

0.077 ± 0.02

0.080 ± 0.01

0.073 ± 0.02

p = 0.013

Cholesterol (mmol/L)

5.75 ± 0.98

5.57 ± 0.98

6.16 ± 1.19

p < 0.001

LDL (mmol/L)

3.89 ± 0.96

3.76 ± 0.98

4.04 ± 0.93

p = 0.138

HDL (mmol/L)

1.39 ± 0.33

1.29 ± 0.27

1.63 ± 0.34

p < 0.001

Plasma glucose (mmol/L)

5.05 ± 0.54

5.11 ± 0.66

4.83 ± 0.93

p = 0.306

Retinal parameters

 

Short time Hypertensive patient

Long time Hypertensive patients

Healthy control subjects

p-value healthy vs hypertensive

p-value healthy vs long time hypertensive

ICD (μm)

22.2 ± 5.2

24.2 ± 6.3

20.1 ± 4.2

p = 0.001

p < 0.001

CapA (−)

1643 ± 602

1462 ± 690

1821 ± 651

p = 0.013

p = 0.005

RCF (AU)

299 ± 72

282 ± 70

314 ± 60

p = 0.032

p = 0.010

OD (μm)

102 ± 12

102 ± 15

107 ± 11

p = 0.038

p = 0.052

ID (μm)

76.1 ± 7.1

75.5 ± 8.5

79.6 ± 8.0

p = 0.004

p = 0.010

WT (μm)

13.2 ± 3.7

13.2 ± 4.4

13.6 ± 3.8

p = 0.552

p = 0.614

WLR (−)

0.345 ± 0.08

0.346 ± 0.10

0.352 ± 0.11

p = 0.693

p = 0.769

CA (μm [2])

3773 ± 1408

3806 ± 1698

3963 ± 1489

p = 0.540

p = 0.646

  1. Data are given as mean ± SD, duration of disease, BMI is given as median and interquartile range, BMI body mass index, BP blood pressure, HR heart rate, LDL low density lipids, HDL high density lipids, RCF retinal capillary flow, ICD intercapillary distance, CapA capillary area, OD outer diameter retinal arteriole, ID inner diameter retinal arteriole, WT wall thickness retinal arteriole, WLR wall to lumen ratio, CA cross sectional area
  2. The data for the healthy control subjects have been previously described by our study group [21]
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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