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Table 2 Characteristics of included studies

From: Periprocedural heparin bridging in patients receiving oral anticoagulation: a systematic review and meta-analysis

First author and year

study design

diagnosis

Operation

sample size

intervention /comparator

Follow-up duration, day

Varkarakis IM, et al.2005 [10]

Retrospective

Atrial fibrillation Mechanical heart valve Venous thromboembolism Other (not specified)

abdominal surgery

B:25

NB:762

B:LMWH and UFH

NB: non-VKA

30

Marquie C, et al.2006 [11]

Retrospective

Atrial fibrillation Mechanical heart valve

Cardiac device implantation

B:114

NB:114

B:LMWH and UFH

NB: non-VKA

30

Wysokinski WE, et al.2008 [12]

Prospective

NVAF

Outpatient dental procedures, Cataract surgery, Other minor outpatient procedures, Open-heart surgery, abdominal vascular surgery, Neurosurgery, Major cancer surgery, Urologic procedures

B:204

NB:182

B:LMWH

NB: interrupt warfarin

30

Garcia DA, et al.2008 [13]

Prospective

Atrial fibrillation Mechanical heart valve Stroke Left ventricular dysfunction Other (not specified)

Biopsy Dental procedures, Dermatological procedures, Endoscopy Neurological procedures, Ophthalmological surgery, Urologic surgery

B:108

NB:1185

B:LMWH and UFH

NB: continue warfarin

30

p.p.karjalainen, et al.2008 [14]

Retrospective

AF

PCI

B:78

NB:66

B:LMWH and UFH

NB: continue warfarin

30

Daniels PR, et al.2009 [15]

Retrospective

MHV

Angiography Biopsies Cardiac procedures, Cardiothoracic surgery, Dental procedures, Endoscopy General surgery, Gynecologic surgery, Head and neck surgery, Miscellaneous procedures, (thoracentesis) Neurological procedures, Neurosurgery Ophthalmological surgery, Orthopedic surgery Urologic surgery, Vascular surgery

B:342

NB:213

B:LMWH and UFH

NB: interrupt warfarin

90

Robinson M, et al.2009 [16]

Retrospective

Not specified

Cardiac device implantation

B:113

NB:35

B:LMWH

NB: interrupt warfarin

7

Tischenko A, et al.2009 [17]

Prospective

Atrial fibrillation Prosthetic heart valve Venous thromboembolism Stroke/transient ischemic attack

Cardiac device implantation

B:38

NB:117

B:LMWH

NB: continue warfarin & NOAC & non-VKA

30

Billett HH, et al.2010 [18]

Retrospective

AF

Not specified

B:265

NB:4532

B:LMWH

NB: interrupt other OAC

30

Ercan M, et al.2010 [19]

Prospective

Atrial fibrillation & MHV& mitral heart valve& Mitral stenosis &Aortic stenosis &Peripheral vascular disease

laparoscopic cholecystectomy

B:44

NB:1421

B:LMWH

NB: non-VKA

30

Ghanbari H, et al.2010 [20]

Retrospective

Atrial fibrillation Mechanical heart valve

Cardiac device implantation

B:29

NB:94

B:LMWH and UFH

NB: interrupt & continue warfarin

30

Jaffer AK, et al.2010 [21]

Prospective

Atrial fibrillation Mechanical heart valve Venous thromboembolism Stroke with patent foramen ovale Cryptogenic stroke Antiphospholipid antibody with thrombosis Dilated cardiomyopathy Multiple indications (not specified)

abdominal surgery, Angiography Cardiothoracic surgery, Dental procedures, Dermatological procedures, Endoscopy, Head and neck surgery, Ophthalmological surgery Orthopedic surgery Vascular surgery

B:229

NB:263

B:LMWH and UFH

NB: interrupt warfarin

30

McBane RD, et al.2010 [22]

Prospective

Venous thromboembolism

abdominal surgery, Cardiothoracic surgery Dental procedures General surgery Gynecologic surgery, Head and neck surgery, Interventional radiology Neurosurgery, Ophthalmological surgery, Orthopedic surgery Plastic surgery, Urologic surgery, Vascular surgery

B:514

NB:216

B:LMWH

NB: interrupt warfarin

90

Tompkins C, et al.2010 [23]

Retrospective

Not specified

Cardiac device implantation

B:154

NB:559

B:LMWH and UFH

NB: interrupt & continue warfarin &non-VKA

42

Smoyer-Tomic K, et al.2012 [24]

Retrospective

AF

Not specified

B:1944

NB:1093

B:LMWH and UFH

NB: interrupt warfarin

30

Healey JS, et al.2012 [25]

Randomized trial

Not specified

pacemaker/defibrillator insertion, dental procedures, diagnostic procedures, cataract removal,colonoscopy, and joint replacement

B:1558

NB:3033

B:LMWH and UFH

NB: NOAC

30

H. Lahtela, et al.2012 [26]

Prospective

AF

PCI

B:290

NB:161

B:LMWH and UFH

NB: continue warfarin & NOAC

30

Birnie DH, et al.2013 [2]

Randomized trial

Not specified

Pacemaker or Defibrillator Surgery

B:338

NB:343

B:LMWH and UFH

NB: continue warfarin

14

Schulman S, et al.2014 [27]

Randomized trial

AF& mechanical valve, bioprosthetic valve, cardiomyopathy, venous thromboembolism, Left ventricle thrombus

pacemaker or defibrillator implantation

B:85

NB:86

B:LMWH

NB: interrupt warfarin

30

Beyer-Westendorf J, et al.2014 [28]

Prospective

SPAF,DVT,PE,OTHER

Superficial skin and oral mucosal surgery, including skin biopsies. Wound revisions. Non-extraction dental treatment. Transluminal cardiac, arterial, and venous interventions. Pacemaker-related surgery. Pleura and ascites puncture. Cataract surgery. Arthroscopy, endoscopy, laparoscopy. Organ biopsies. Dental extraction. Hernia repair. Intramuscular and paravertebral injections. Open pelvic, abdominal and thoracic surgery. Brain surgery. Major orthopaedic and trauma surgery. Vascular surgery.

B:257

NB:606

B:LMWH

NB: NOAC

30

Kim, T. H.2015 [29]

Retrospective

AF

Not specified

B:1053

NB:4274

B:UFH

NB: interrupt warfarin

30

Steinberg BA, et al.2015 [7]

Prospective

AF

Not specified

B:514

NB:1766

B:LMWH and UFH

NB: interrupt warfarin & NOAC

730

Douketis JD, et al.2015 [8]

Randomized trial

AF

Not specified

B:895

NB:918

B:LMWH

NB: interrupt warfarin

30

Douketis JD, et al.2015 [30]

Randomized trial

AF

day surgery/procedure, pacemaker/ICD,PCI, dental procedure, diagnostic procedure, other

B:800

NB:3306

B:LMWH and UFH

NB: interrupt warfarin & NOAC

30

Dewilde WJM, et al.2015 [31]

Randomized trial

Not specified

PCI

B:322

NB:241

B:LMWH and UFH

NB: continue warfarin

365