Fig. 3

Typical pictures and quantified analysis of myocardial apoptosis in rats from every 6 h after CME modeling: TUNEL staining conclusions. The staining of apoptotic cardiomyocyte nuclei (arrows) are brown (×400), bar = 25 μm. Conclusions of quantified detection revealed that the apoptotic coefficients of myocardium were mainly higher in the CME or the control groups contrasted with those in Nrf2 groups. a Sham; b CME; c AAV- Nrf2(CME); d AAV-control (CME); e the histogram of the apoptotic index of each group of rats. AAV-Nrf2(CME): rats injected Nrf2 undergone CME operation; AAV-control (CME): rats injected AAV-control undergone CME operation; CME: coronary microembolization; Nrf 2: nuclear factor erythroid 2-like; AAV: adeno-associated virus. Data is presented as Mean ± SD a: P < 0.05 contrasted with sham; b: P < 0.05 compared with CME or AAV control (CME)