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Fig. 2 | BMC Cardiovascular Disorders

Fig. 2

From: Deletion of the NR4A nuclear receptor NOR1 in hematopoietic stem cells reduces inflammation but not abdominal aortic aneurysm formation

Fig. 2

Genetic NOR1 Deletion Impaired Inflammatory Gene Expression. BMDM isolated from NOR1+/+ or NOR1−/− mice (n = 6 mice per group) were incubated with 100 ng/ml LPS for 8 h before harvesting RNA for nCounter gene expression profiling. RNA from two mice of the same strain were pooled together and analyzed for transcript expression. a-c. Histograms of genes which revealed more than 50% difference in transcript abundance in response to LPS-stimulation of NOR1+/+ and NOR1−/− BMDM. Data was processed using the nSolver software and presented as fold increase relative to untreated BMDM of the same genotype. Values are mean ± SEM (* P < 0.05 vs. NOR1+/+)

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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