ARVC Total (N = 155) | ECG-positive ARVC (N = 89) | ECG-negative ARVC (N = 66) | p-value ECG-positive vs ECG-negative | |
---|---|---|---|---|
Age | 42.1 ± 17.3 | 42.0 ± 17.4 | 41.7 ± 17.6 | 0.861 |
Sex (% male) | 106 (68.4%) | 63 (70.8%) | 43 (65.2%) | 0.488 |
Proband (%) | 111 (71.6%) | 71 (79.8%) | 30 (45.5%) | 0.012 |
I. Imaging | 155 (100%) | 89 (100%) | 66 (100%) | 1.000 |
major, % | 111 (71.6%) | 68 (76.4%) | 43 (65.2%) | 0.082 |
minor, % | 89 (57.4%) | 60 (67.4%) | 29 (43.9%) | 0.005 |
II. Tissue characterization of the wall, biopsies performed (% of patients) | 70 (45.2%) | 39 (43.8%) | 31 (47.0%) | 0.745 |
major, % | 53 (75.7%) | 31 (79.1%) | 22 (71.0%) | 0.576 |
minor, % | 63 (90.0%) | 36 (92.3%) | 27 (87.1%) | 0.454 |
III. Repolarization abnormality | ||||
major, % | 54 (34.8%) | 54 (60.7%) | 0 (0.0%) | <0.001 |
minor, % | 20 (12.9%) | 20 (22.5%) | 0 (0.0%) | <0.001 |
IV. Depolarization abnormality | ||||
major, % | 13 (8.4%) | 13 (14.6%) | 0 (0.0%) | <0.001 |
minor, % | 17 (11.0%) | 17 (19.1%) | 0 (0.0%) | <0.001 |
V. Arrhythmia | ||||
major, % | 44 (28.4%) | 26 (29.2%) | 18 (27.3%) | 0.858 |
minor, % | 64 (41.3%) | 42 (47.2%) | 22 (33.3%) | 0.1000 |
VI. Family history | ||||
major, % | 84 (54.2%) | 48 (53.9%) | 35 (53.0%) | 1.000 |
VII. Genotype positive | 48 (31.0%) | 29 (32.6%) | 19 (28.8%) | 0.726 |
PLN (% genotype positive) | 1 (2.1%) | 0 (0.0%) | 1 (5.3%) | 0.396 |
TTN (% genotype positive) | 11 (22.9%) | 8 (27.6%) | 3 (15.8%) | 0.488 |
PKP2 (% genotype positive) | 23 (47.9%) | 17 (58.6%) | 6 (31.2%) | 0.083 |
DSC2 (% genotype positive) | 2 (4.2%) | 1 (3.5%) | 1 (5.3%) | 1.000 |
DSG2 (% genotype positive) | 12 (25.0%) | 6 (20.7%) | 6 (31.5%) | 0.501 |
DSG3 (% genotype positive) | 2 (4.2%) | 1 (3.5%) | 1 (5.30%) | 1.000 |
DSP (% genotype positive) | 8 (16.7%) | 6 (20.7%) | 2 (10.56%) | 0.4510 |