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Table 7 Percentage of subgroups for positive FH as defined by the SB, US MEDPED and JFHC against the subgroups for positive FH as defined by the DLCC definition

From: Diagnostic performance of various familial hypercholesterolaemia diagnostic criteria compared to Dutch lipid clinic criteria in an Asian population

Definitions DLCC
Definite FH N = 130 (%) Probable FH N = 45 (%) Possible FHN = 240 (%) Unlikely FH N = 340 (%) p-value
Simon Broome
Definite FH 124 (95.4) 24 (53.3) 0 (0) 0 <0.001*
Possible FH 2 (1.5) 12(26.7) 50 (20.8) 4 (1.2)
No FH 4 (3.0) 9 (0.2) 190 (79.2) 336 (98.8)
Total 130 45 240 340 755
US MEDPED
Heterozygous 66 (50.8) 21 (46.7) 18 (7.5) 2 (0.6) <0.001*
No FH 64 (49.2) 24 (53.3) 222 (92.5) 338 (99.4)
Total 130 45 240 340 755
JFHC
Heterozygous 124 (95.4) 32 (71.1) 37 (15.4) 4 (1.2) <0.001*
Homozygous 2 (1.5) 0 0 0
No FH 4 (3.1) 13 (28.9) 203 (84.6) 336 (98.8)
Total 130 45 240 340 755
  1. Significant = *p < 0.05; FH = Familial Hypercholesterolaemia; DLCC = Dutch Lipid Clinic Criteria; SB = Simon Broome’s Register Criteria; USMEDPED = US Make Early Diagnosis to Prevent Early Deaths criteria; JFHMC = Japanese Familial Hypercholesterolaemia Management Criteria. Pearson correlation