Skip to main content

Table 7 Percentage of subgroups for positive FH as defined by the SB, US MEDPED and JFHC against the subgroups for positive FH as defined by the DLCC definition

From: Diagnostic performance of various familial hypercholesterolaemia diagnostic criteria compared to Dutch lipid clinic criteria in an Asian population

Definitions

DLCC

Definite FH N = 130 (%)

Probable FH N = 45 (%)

Possible FHN = 240 (%)

Unlikely FH N = 340 (%)

p-value

Simon Broome

Definite FH

124 (95.4)

24 (53.3)

0 (0)

0

<0.001*

Possible FH

2 (1.5)

12(26.7)

50 (20.8)

4 (1.2)

No FH

4 (3.0)

9 (0.2)

190 (79.2)

336 (98.8)

Total

130

45

240

340

755

US MEDPED

Heterozygous

66 (50.8)

21 (46.7)

18 (7.5)

2 (0.6)

<0.001*

No FH

64 (49.2)

24 (53.3)

222 (92.5)

338 (99.4)

Total

130

45

240

340

755

JFHC

Heterozygous

124 (95.4)

32 (71.1)

37 (15.4)

4 (1.2)

<0.001*

Homozygous

2 (1.5)

0

0

0

No FH

4 (3.1)

13 (28.9)

203 (84.6)

336 (98.8)

Total

130

45

240

340

755

  1. Significant = *p < 0.05; FH = Familial Hypercholesterolaemia; DLCC = Dutch Lipid Clinic Criteria; SB = Simon Broome’s Register Criteria; USMEDPED = US Make Early Diagnosis to Prevent Early Deaths criteria; JFHMC = Japanese Familial Hypercholesterolaemia Management Criteria. Pearson correlation