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Table 6 Sensitivity, specificity, positive predictive value and negative predictive value for positive FH as defined by the SB, US MEDPED and JFHMC definitions against the DLCC definition

From: Diagnostic performance of various familial hypercholesterolaemia diagnostic criteria compared to Dutch lipid clinic criteria in an Asian population

Definitions DLCC
Yes FH No FH TOTAL Sensitivity(%) Specificity (%) PPV (%) NPV (%) Efficiency (%) p-value
  Simon Broome
Positive FH 212 4 216 51.1 98.8 98.1 62.3 28.6 <0.001*
Negative FH 203 336 539
TOTAL 415 340 755       
  US MEDPED
Positive FH 105 2 107 25.3 99.4 98.1 56.1 14.1 <0.001*
Negative FH 310 338 648
TOTAL 415 340 755  
  JFHMC
Positive FH 195 4 199 47.0 98.8 97.9 60.4 26.4 <0.001*
Negative FH 220 336 556
TOTAL 415 340 755  
  1. Significant = *p < 0.05; FH = Familial Hypercholesterolaemia; DLCC = Dutch Lipid Clinic Criteria; SB = Simon Broome’s Register Criteria; USMEDPED = US Make Early Diagnosis to Prevent Early Deaths criteria; JFHMC = Japanese Familial Hypercholesterolaemia Management Criteria; PPV: positive predictive value, NPV: Negative Predictive Value. Pearson correlation