Table 4 Diagnostic criteria for adult (15 years or older) homozygous FH by the Japanese FH Management Guideline Criteria

Hypercholesterolaemia (serum total cholesterol before treatment: ≥ 15.5 mmol/L)

Tendon xanthomata (tendon xanthoma on the dorsal hands, elbows, and knees, or Achilles tendon thickening¹) or nodular xanthoma on the skin

Premature CAD during childhood

Parents’ family history of heterozygous FH.

Diagnostic criteria for adult (15 years or older) heterozygous FH by the Japanese FH Management Guideline Criteria

Hyper- LDL cholesteroalemia (LDL-C before treatment: ≥ 4.7 mmol/L)

Tendon xanthomata (tendon xanthoma on the dorsal hands, elbows, and knees, or Achilles tendon thickening) or nodular xanthoma on the skin

Family history within the second- degree relatives FH or premature CAD (men <55, women <60 years)