Skip to main content

Table 4 Diagnostic criteria for adult (15 years or older) homozygous FH by the Japanese FH Management Guideline Criteria

From: Diagnostic performance of various familial hypercholesterolaemia diagnostic criteria compared to Dutch lipid clinic criteria in an Asian population

Hypercholesterolaemia (serum total cholesterol before treatment: ≥ 15.5 mmol/L)
Tendon xanthomata (tendon xanthoma on the dorsal hands, elbows, and knees, or Achilles tendon thickening1) or nodular xanthoma on the skin
Premature CAD during childhood
Parents’ family history of heterozygous FH.
Diagnostic criteria for adult (15 years or older) heterozygous FH by the Japanese FH Management Guideline Criteria
Hyper- LDL cholesteroalemia (LDL-C before treatment: ≥ 4.7 mmol/L)
Tendon xanthomata (tendon xanthoma on the dorsal hands, elbows, and knees, or Achilles tendon thickening) or nodular xanthoma on the skin
Family history within the second- degree relatives FH or premature CAD (men <55, women <60 years)
  1. 1Patients with Achilles tendon thickening (≥9 mm) on radiography should be regarded as having xanthoma