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Table 2 Dutch Lipid Clinic network diagnosis of FH

From: Diagnostic performance of various familial hypercholesterolaemia diagnostic criteria compared to Dutch lipid clinic criteria in an Asian population

Criteria Points
Family History  
A First degree relative with known premature (<55 years men; < 60 years women) coronary disease and vascular disease OR LDL-c > 95th percentile 1
B First degree relative with tendon xanthomata and/or arcuscornealis OR childhood (<18 years) with LDL-c > 95th percentile 2
Clinical history  
A Patient with premature CAD (men <55, women <60 years) 2
B Patient with premature cerebral or PVD (men <55, women <60 years) 1
Physical Examination  
A Tendon xanthomas 6
B Premature arcus 4
Lab analysis
A LDL – c > 8.5 mmol/L
8
B LDL-c 6.5–8.4 mmol/L 5
C LDL- c 5.0–6.4 mmol/L 3
D LDL – c 4.0–4.9 mmol/L 1
Functional  
DNA mutations 8
Definite FH: > 8 points, Probable FH: 6–8 points, Possible FH: 3–5