Criteria | Points |
---|---|
Family History | |
A First degree relative with known premature (<55 years men; < 60 years women) coronary disease and vascular disease OR LDL-c > 95th percentile | 1 |
B First degree relative with tendon xanthomata and/or arcuscornealis OR childhood (<18 years) with LDL-c > 95th percentile | 2 |
Clinical history | |
A Patient with premature CAD (men <55, women <60 years) | 2 |
B Patient with premature cerebral or PVD (men <55, women <60 years) | 1 |
Physical Examination | |
A Tendon xanthomas | 6 |
B Premature arcus | 4 |
Lab analysis A LDL – c > 8.5 mmol/L | 8 |
B LDL-c 6.5–8.4 mmol/L | 5 |
C LDL- c 5.0–6.4 mmol/L | 3 |
D LDL – c 4.0–4.9 mmol/L | 1 |
Functional | |
DNA mutations | 8 |
Definite FH: > 8 points, Probable FH: 6–8 points, Possible FH: 3–5 |