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Table 2 Dutch Lipid Clinic network diagnosis of FH

From: Diagnostic performance of various familial hypercholesterolaemia diagnostic criteria compared to Dutch lipid clinic criteria in an Asian population

Criteria

Points

Family History

 

A First degree relative with known premature (<55 years men; < 60 years women) coronary disease and vascular disease OR LDL-c > 95th percentile

1

B First degree relative with tendon xanthomata and/or arcuscornealis OR childhood (<18 years) with LDL-c > 95th percentile

2

Clinical history

 

A Patient with premature CAD (men <55, women <60 years)

2

B Patient with premature cerebral or PVD (men <55, women <60 years)

1

Physical Examination

 

A Tendon xanthomas

6

B Premature arcus

4

Lab analysis

A LDL – c > 8.5 mmol/L

8

B LDL-c 6.5–8.4 mmol/L

5

C LDL- c 5.0–6.4 mmol/L

3

D LDL – c 4.0–4.9 mmol/L

1

Functional

 

DNA mutations

8

Definite FH: > 8 points, Probable FH: 6–8 points, Possible FH: 3–5