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Table 3 Predictors for antihypertensive treatment non-persistence in three propensity-matched cohorts a

From: Persistence with antihypertensives in uncomplicated treatment-naïve very elderly patients: a nationwide population-based study

Characteristics Adults (n = 6689) Elderly (n = 6689) Very elderly (n = 6689)
aHR 95% CI aHR 95% CI aHR 95% CI
Sex
 Male (reference) 1.00   1.00   1.00  
 Female 0.90 0.82–0.98 0.92 0.84–1.01 0.85 0.78–0.93
Charlson comorbidity index score
 0 (reference) 1.00   1.00   1.00  
  ≥ 1 0.95 0.87–1.03 0.98 0.92–1.04 0.93 0.87–0.98
Health insurance type
 Health insurance (reference) 1.00   1.00   1.00  
 Medical aid 1.21 1.06–1.39 1.07 0.92–1.26 0.83 0.71–0.98
Underlying disease risk factor
 Dementia 1.66 0.93–2.97 1.15 0.75–1.77 0.68 0.52–0.90
 Depression 1.11 0.95–1.28 1.36 1.00–1.85 0.91 0.63–1.32
 Dyslipidaemia 0.64 0.59–0.71 0.75 0.61–0.92 0.75 0.57–0.98
Therapeutic class of index therapy
 Angiotensin receptor blockers (reference) 1.00   1.00   1.00  
 Dihydropyridine calcium channel blockers 1.12 1.02–1.22 1.03 0.93–1.13 1.04 0.94–1.14
 Selective beta blockers 1.93 1.73–2.16 1.58 1.37–1.82 1.29 1.11–1.51
 Thiazide diuretics 4.04 3.49–4.67 2.87 2.48–3.33 1.74 1.51–2.02
 Alpha blockers 1.90 1.15–3.15 1.23 0.92–1.65 1.03 0.81–1.30
 Angiotensin converting enzyme inhibitors 1.42 1.03–1.97 1.14 0.77–1.68 0.96 0.68–1.37
 Others 2.39 1.18–4.88     
  1. Abbreviations: aHR adjusted hazard ratio; CI confidence interval
  2. aPredictors for antihypertensive treatment non-persistence were identified using a multivariate Cox-proportional Hazard model