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Table 3 Predictors for antihypertensive treatment non-persistence in three propensity-matched cohorts a

From: Persistence with antihypertensives in uncomplicated treatment-naïve very elderly patients: a nationwide population-based study

Characteristics

Adults (n = 6689)

Elderly (n = 6689)

Very elderly (n = 6689)

aHR

95% CI

aHR

95% CI

aHR

95% CI

Sex

 Male (reference)

1.00

 

1.00

 

1.00

 

 Female

0.90

0.82–0.98

0.92

0.84–1.01

0.85

0.78–0.93

Charlson comorbidity index score

 0 (reference)

1.00

 

1.00

 

1.00

 

  ≥ 1

0.95

0.87–1.03

0.98

0.92–1.04

0.93

0.87–0.98

Health insurance type

 Health insurance (reference)

1.00

 

1.00

 

1.00

 

 Medical aid

1.21

1.06–1.39

1.07

0.92–1.26

0.83

0.71–0.98

Underlying disease risk factor

 Dementia

1.66

0.93–2.97

1.15

0.75–1.77

0.68

0.52–0.90

 Depression

1.11

0.95–1.28

1.36

1.00–1.85

0.91

0.63–1.32

 Dyslipidaemia

0.64

0.59–0.71

0.75

0.61–0.92

0.75

0.57–0.98

Therapeutic class of index therapy

 Angiotensin receptor blockers (reference)

1.00

 

1.00

 

1.00

 

 Dihydropyridine calcium channel blockers

1.12

1.02–1.22

1.03

0.93–1.13

1.04

0.94–1.14

 Selective beta blockers

1.93

1.73–2.16

1.58

1.37–1.82

1.29

1.11–1.51

 Thiazide diuretics

4.04

3.49–4.67

2.87

2.48–3.33

1.74

1.51–2.02

 Alpha blockers

1.90

1.15–3.15

1.23

0.92–1.65

1.03

0.81–1.30

 Angiotensin converting enzyme inhibitors

1.42

1.03–1.97

1.14

0.77–1.68

0.96

0.68–1.37

 Others

2.39

1.18–4.88

    
  1. Abbreviations: aHR adjusted hazard ratio; CI confidence interval
  2. aPredictors for antihypertensive treatment non-persistence were identified using a multivariate Cox-proportional Hazard model