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Table 1 Characteristics of the included studies

From: Migraine and percutaneous patent foramen ovale closure: a systematic review and meta-analysis

Author, year

Length of follow-up

Method of outcome assessment

Grade of evidence

Subgroup

Preclosure

Postprocedural therapy

Schwerzman et al., 2004 [25]

1 Y

A detailed questionnaire

Low

MA

Attack frequency: 1.2 ± 0.8/M

Number of large shunt: 27

Aspirin 100 mg/d 6 M

Clopidogrel 75 mg/d 1 M

    

MwoA

Attack frequency: 1.2 ± 0.7/M

Number of large shunt: 6

Ditto

Azarbal et al., 2005 [21]

1 Y

MIDAS questionnaire

Low

MA

NA

Aspirin 325 mg/d 3 M

clopidogrel 75 mg/d 3 M

    

MwoA

Ditto

Ditto

Slavin et al., 2007 [26]

30 ± 16 M

MIDAS Score

Low

MA

MIDAS Score: 48.3 ± 11.8

NA

    

MwoA

MIDAS Score: 43.2 ± 11.9

Ditto

Reisman et al., 2005 [24]

1 Y

Migraine questionnaire

Low

MA

NA

Aspirin 325 mg/d 6 M

Clopidogrel 75 mg/d 3 M

    

MwoA

Ditto

Ditto

Jesurum et al., 2008 [23]

1.5 Y

Migraine questionnaire

Low

MA

Attack frequency: 5.1 ± 7.5/M

Number of large shunt: 51

Aspirin 325 mg/d 6 M

Clopidogrel 75 mg/d 3 M

    

MwoA

Attack frequency: 4.8 ± 6.7/M

Number of large shunt: 20

Ditto

Dubiel et al., 2007 [22]

Mean 38 M

A structured questionnaire

Low

MA

NA

Aspirin 100 mg/d 6 M

    

MwoA

Ditto

Ditto

Whal et al., 2010 [27]

5.0 ± 1.9 Y

A structured questionnaire

Low

MA

Attack frequency: 1/d 3

Number of large shunt: 76

Acetylsalicylic 100 mg/d 6 M

Clopidogrel 75 mg/d 6 M

    

MwoA

Attack frequency: 1/d 1

Number of large shunt: 46

Ditto

Rigatelli et al., 2012 [18]

24–76 M

MIDAS

Low

MA

Attack frequency: 1.1 ± 0.2/M

NA

    

MwoA

Attack frequency: 4.2 ± 0.8/M

Ditto

  1. M months, MA migraine with aura, MIDAS Migraine Disability Assessment Test, MwoA migraine without aura, Y years