Table 8 Frequencies of TFPI polymorphisms in two populations according to hyperlipidemia
From: Association study to evaluate TFPI gene in CAD in Han Chinese
SNP | genotype | Population 1 | Population 2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
hyperlipidemia | Non- hyperlipidemia | hyperlipidemia | Non- hyperlipidemia | ||||||||||
CAD n (%) | Non-CAD n (%) | P | CAD n (%) | Non-CAD n (%) | P | CAD n (%) | Non-CAD n (%) | P | CAD n (%) | Non-CAD n (%) | P | ||
Rs8176528 | GG | 439 | 521 | 0.074 | 369 | 308 | 0.651 | 314 | 181 | 0.580 | 149 | 277 | 0.166 |
356 | 447 | 300 | 247 | 269 | 157 | 111 | 227 | ||||||
(81.1) | (85.8) | (81.3) | (80.2) | (85.7) | (86.7) | (74.5) | (81.9) | ||||||
AA | 21 | 25 | Â | 19 | 21 | Â | 10 | 8 | Â | 8 | 13 | Â | |
(4.8) | (4.8) | (5.1) | (6.8) | (3.2) | (4.4) | (5.4) | (4.7) | ||||||
GA | 62 | 49 | Â | 50 | 40 | Â | 35 | 16 | Â | 30 | 37 | Â | |
(14.1) | (9.4) | (13.6) | (13.0) | (11.1) | (8.9) | (20.1) | (13.4) | ||||||
Rs10153820 | GG | 439 | 521 | 0.301 | 369 | 308 | 0.848 | 314 | 181 | 0.788 | 149 | 277 | 0.688 |
217 | 251 | 198 | 169 | 196 | 110 | 89 | 176 | ||||||
(49.4) | (48.2) | (53.7) | (54.9) | (62.4) | (60.8) | (59.7) | (63.5) | ||||||
AA | 20 | 36 | Â | 28 | 20 | Â | 53 | 35 | Â | 28 | 44 | Â | |
(4.6) | (6.9) | (7.6) | (6.5) | (16.9) | (19.3) | (18.8) | (15.9) | ||||||
GA | 202 | 234 | Â | 143 | 119 | Â | 65 | 36 | Â | 32 | 57 | Â | |
(46.0) | (44.9) | (38.7) | (38.6) | (20.7) | (19.9) | (21.5) | (20.6) | ||||||
439 | 521 | 369 | 308 | 314 | 181 | 149 | 277 | ||||||
Rs6434222 | TT | 252 | 321 | 0.002 | 181 | 175 | <0.001 | 158 | 125 | <0.001 | 77 | 160 | <0.001 |
(57.4) | (61.6) | (49.1) | (56.8) | (50.3) | (69.1) | (51.7) | (57.8) | ||||||
AA | 28 | 58 | Â | 20 | 41 | Â | 6 | 19 | Â | 5 | 41 | Â | |
(6.4) | (11.1) | (5.4) | (13.3) | (1.9) | (10.5) | (3.4) | (14.8) | ||||||
TA | 159 | 142 | Â | 168 | 92 | Â | 150 | 37 | Â | 67 | 76 | Â | |
(36.2) | (27.3) | (45.5) | (29.9) | (47.8) | (20.4) | (44.9) | (27.4) | ||||||
Rs7586970 | TT | 439 | 521 | 0.117 | 369 | 308 | 0.125 | 314 | 181 | 0.064 | 149 | 277 | 0.073 |
372 | 449 | 309 | 254 | 252 | 160 | 132 | 231 | ||||||
(84.7) | (86.2) | (83.7) | (82.5) | (80.3) | (88.4) | (88.6) | (83.4) | ||||||
CC | 19 | 32 | Â | 17 | 25 | Â | 16 | 6 | Â | 5 | 26 | Â | |
(4.3) | (6.1) | (4.6) | (8.1) | (5.1) | (3.3) | (3.4) | (9.4) | ||||||
TC | 48 | 40 | Â | 43 | 29 | Â | 46 | 15 | Â | 12 | 20 | Â | |
(11.0) | (7.7) | (11.7) | (9.4) | (14.6) | (8.3) | (8.0) | (7.2) | ||||||