Table 7 Frequencies of TFPI polymorphisms in two populations according to hypertension
From: Association study to evaluate TFPI gene in CAD in Han Chinese
SNP | genotype | Population 1 | Population 2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
hypertension | Non-hypertension | hypertension | Non-hypertension | ||||||||||
CAD n (%) | Non-CAD n (%) | P | CAD n (%) | Non-CAD n (%) | P | CAD n (%) | Non-CAD n (%) | P | CAD n (%) | Non-CAD n (%) | P | ||
Rs8176528 | GG | 528 | 311 | 0.074 | 280 | 518 | 0.403 | 294 | 118 | 0.477 | 169 | 340 | 0.707 |
428 | 271 | 228 | 423 | 238 | 100 | 142 | 284 | ||||||
(81.1) | (87.1) | (81.4) | (81.7) | (81.0) | (84.7) | (84.0) | (83.5) | ||||||
AA | 26 | 10 | Â | 14 | 36 | Â | 13 | 6 | Â | 5 | 15 | Â | |
(4.9) | (3.2) | (5.0) | (6.9) | (4.4) | (5.1) | (3.0) | (4.4) | ||||||
GA | 74 | 30 | Â | 38 | 59 | Â | 43 | 12 | Â | 22 | 41 | Â | |
(14.0) | (9.7) | (13.6) | (11.4) | (14.6) | (10.2) | (13.0) | (12.1) | ||||||
Rs10153820 | GG | 528 | 311 | 0.327 | 280 | 518 | 0.381 | 294 | 118 | 0.744 | 169 | 340 | 0.797 |
268 | 174 | 147 | 246 | 175 | 75 | 110 | 211 | ||||||
(50.8) | (55.9) | (52.5) | (47.5) | (59.5) | (63.6) | (65.1) | (62.1) | ||||||
AA | 31 | 18 | Â | 17 | 38 | Â | 54 | 19 | Â | 27 | 60 | Â | |
(5.8) | (5.8) | (6.1) | (7.3) | (18.4) | (16.1) | (16.0) | (17.6) | ||||||
GA | 229 | 119 | Â | 116 | 234 | Â | 65 | 24 | Â | 32 | 69 | Â | |
(43.4) | (38.3) | (41.4) | (45.2) | (22.1) | (20.3) | (18.9) | (20.3) | ||||||
Rs6434222 | TT | 528 | 311 | <0.001 | 280 | 518 | 0.002 | 294 | 118 | <0.001 | 169 | 340 | <0.001 |
274 | 194 | 159 | 302 | 146 | 60 | 89 | 225 | ||||||
(51.9) | (62.4) | (56.8) | (58.3) | (49.7) | (50.8) | (52.7) | (66.2) | ||||||
AA | 33 | 37 | Â | 15 | 62 | Â | 8 (2.7) | 21 | Â | 3 | 39 | Â | |
(6.3) | (11.9) | (5.4) | (12.0) | Â | (17.8) | (1.8) | (11.5) | ||||||
TA | 221 | 80 | Â | 106 | 154 | Â | 140 | 37 | Â | 77 | 76 | Â | |
(41.8) | (25.7) | (37.8) | (29.7) | (47.6) | (31.4) | (45.5) | (22.3) | ||||||
Rs7586970 | TT | 528 | 311 | 0.250 | 280 | 518 | 0.078 | 294 | 118 | 0.312 | 169 | 340 | 0.158 |
448 | 262 | 233 | 441 | 241 | 98 | 143 | 293 | ||||||
(84.8) | (84.2) | (83.3) | (85.2) | (82.0) | (83.1) | (84.6) | (86.2) | ||||||
CC | 23 | 21 | Â | 13 | 36 | Â | 14 | 9 | Â | 7 | 23 | Â | |
(4.4) | (6.8) | (4.6) | (6.9) | (4.8) | (7.6) | (4.1) | (6.8) | ||||||
TC | 57 | 28 | Â | 34 | 41 | Â | 39 | 11 | Â | 19 | 24 | Â | |
(10.8) | (9.0) | (12.1) | (7.9) | (13.2) | (9.3) | (11.3) | (7.0) | ||||||