Table 6 Frequencies of TFPI polymorphisms in two populations according to smoking status
From: Association study to evaluate TFPI gene in CAD in Han Chinese
SNP | genotype | Population 1 | Population 2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
smoking | Non- smoking | smoking | Non- smoking | ||||||||||
CAD n (%) | Non-CAD n (%) | P | CAD n (%) | Non-CAD n (%) | P | CAD n (%) | Non-CAD n (%) | P | CAD n (%) | Non-CAD n (%) | P | ||
Rs8176528 | GG | 367 | 111 | 0.695 | 441 | 718 | 0.273 | 269 | 232 | 0.581 | 194 | 226 | 0.063 |
298 | 93 | 358 | 601 | 233 | 194 | 147 | 190 | ||||||
(81.2) | (83.8) | (81.2) | (83.7) | (86.6) | (83.6) | (75.8) | (84.1) | ||||||
AA | 18 | 6 | Â | 22 | 40 | Â | 7 | 9 | Â | 11 | 12 | Â | |
(4.9) | (5.4) | (5.0) | (5.6) | (2.6) | (3.9) | (5.7) | (5.3) | ||||||
GA | 51 | 12 | Â | 61 | 77 | Â | 29 | 29 | Â | 36 | 24 | Â | |
(13.9) | (10.8) | (13.8) | (10.7) | (10.8) | (12.5) | (18.5) | (10.6) | ||||||
Rs10153820 | GG | 367 | 111 | 0.998 | 441 | 718 | 0.827 | 269 | 232 | 0.871 | 194 | 226 | 0.988 |
184 | 56 | 231 | 364 | 164 | 146 | 121 | 140 | ||||||
(50.1) | (50.5) | (52.4) | (50.7) | (61.0) | (62.9) | (62.4) | (61.9) | ||||||
AA | 20 | 6 | Â | 28 | 50 | Â | 48 | 41 | Â | 33 | 38 | Â | |
(5.4) | (5.4) | (6.3) | (7.0) | (17.8) | (17.7) | (17.0) | (16.9) | ||||||
GA | 163 | 49 | Â | 182 | 304 | Â | 57 | 45 | Â | 40 | 48 | Â | |
(44.5) | (44.1) | (41.3) | (42.3) | (21.2) | (19.4) | (20.6) | (21.2) | ||||||
Rs6434222 | TT | 367 | 111 | 0.021 | 441 | 718 | <0.001 | 269 | 232 | <0.001 | 194 | 226 | <0.001 |
178 | 64 | 255 | 432 | 136 | 132 | 99 | 153 | ||||||
(48.5) | (57.7) | (57.8) | (60.2) | (50.6) | (56.9) | (51.0) | (67.7) | ||||||
AA | 20 | 11 | Â | 28 | 88 | Â | 7 | 39 | Â | 4 | 21 | Â | |
(5.4) | (9.9) | (6.3) | (12.3) | (2.6) | (16.8) | (2.1) | (9.3) | ||||||
TA | 169 | 36 | Â | 158 | 198 | Â | 126 | 61 | Â | 91 | 52 | Â | |
(46.1) | (32.4) | (35.9) | (27.5) | (46.8) | (26.3) | (46.9) | (23.0) | ||||||
Rs7586970 | TT | 367 | 111 | 0.749 | 441 | 718 | 0.064 | 269 | 232 | 0.081 | 194 | 226 | 0.202 |
306 | 92 | 375 | 611 | 221 | 194 | 163 | 197 | ||||||
(83.4) | (82.9) | (85.0) | (85.1) | (82.2) | (83.7) | (84.0) | (87.2) | ||||||
CC | 17 | 7 | Â | 19 | 50 | Â | 12 | 18 | Â | 9 | 14 | Â | |
(4.6) | (6.3) | (4.3) | (7.0) | (4.4) | (7.7) | (4.6) | (6.2) | ||||||
TC | 44 | 12 | Â | 47 | 57 | Â | 36 | 20 | Â | 22 | 15 | Â | |
(12.0) | (10.8) | (10.7) | (7.9) | (13.4) | (8.6) | (11.4) | (6.6) | ||||||