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Table 3 Frequency of TFPI polymorphism in CAD population from two regions

From: Association study to evaluate TFPI gene in CAD in Han Chinese

  

Population 1

 

Population 2

 

SNP

genotype

CAD n (%)

Non-CAD n (%)

P

CAD n (%)

Non-CAD n (%)

P

rs8176528

 

808

829

 

463

458

 
 

GG

656 (81.2)

694 (83.7)

0.146

380 (82.1)

384 (83.8)

0.486

 

AA

GA

40 (5.0)

112 (13.8)

46 (5.6)

89 (10.7)

 

18 (3.9)

65 (14.0)

21 (4.6)

53 (11.6)

 

Allelic A frequency (%)

11.8

10.9

 

10.9

10.3

 

rs10153820

 

808

829

 

463

458

 
 

GG

415 (51.4)

420 (50.7)

0.792

285 (61.6)

286 (62.5)

0.959

 

AA

GA

48 (5.9)

345 (42.7)

56 (6.7)

353 (42.6)

 

81 (17.5)

97 (20.9)

79 (17.2)

93 (20.3)

 

Allelic A frequency (%)

27.3

28.0

 

27.9

27.4

 

rs6434222

 

808

829

 

463

458

 
 

TT

433 (53.6)

496 (59.8)

<0.001

235 (50.7)

285 (62.2)

<0.001

 

AA

TA

48 (5.9)

327 (40.5)

99 (11.9)

234 (28.3)

 

11 (2.4)

217 (46.9)

60 (13.1)

113 (24.7)

 

Allelic A frequency (%)

26.2

26.1

 

25.8

25.4

 

rs7586970

 

808

829

 

463

458

 
 

TT

681 (84.3)

703 (84.8)

0.020

384 (82.9)

391 (85.4)

0.018

 

CC

TC

36 (4.5)

91 (11.2)

57 (6.9)

69 (8.3)

 

21 (4.5)

58 (12.6)

32 (7.0)

35 (7.6)

 

Allelic C frequency (%)

10.1

11.0

 

10.8

10.8

 
  1. Calculations are performed with comparison of three different genotypes. Values are the number (percentage) of subjects. Significant differences were drawn in frequencies of rs7586970 and rs6434222 between CAD cases and non-CAD controls