Plasma homocysteine levels associated with a corrected QT interval

Table 3 Multivariable logistic regression analyses for association between homocysteine and long QTc interval

Homocysteine (quartiles)	Model 1			Model 2			Model 3			Model 4
Homocysteine (quartiles)	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value
Q1 (≤11.1)	1.205	1.038–1.399	0.014	1.196	1.030–1.390	0.019	1.203	1.031–1.404	0.019	1.226	1.049–1.432	0.010
Q2 (>11.1 and ≤13.8)		1.000 (reference)			1.000 (reference)			1.000 (reference)			1.000 (reference)
Q3 (>13.8 and ≤18.2)	1.135	0.974–1.323	0.104	1.133	0.972–1.321	0.110	1.134	0.969–1.326	0.117	1.128	0.963–1.321	0.137
Q4 (>18.2)	1.504	1.287–1.758	<0.001	1.486	1.270–1.739	<0.001	1.408	1.197–1.656	<0.001	1.398	1.187–1.646	<0.001

Model 1: adjusted for age, sex and race
Model 2: adjusted for factors in model 1 and education level, family income, dietscore, sleep duration, current smoking, drinking status, and physical activity
Model 3: adjusted for factors in model 2 and and body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, total cholesterol
triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, fasting plasma glucose
Model 4: adjusted for factors in model 3 and serum calcium, potassium and magnesium, history of heart disease and any medication
Abbreviations: QTc corrected QT, OR odds ratio, 95% CI 95% confidence interval

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