The influence of dehydration on the prognosis of acute ischemic stroke for patients treated with tissue plasminogen activator

Table 4 Multivariate analysis of variables associated with prognosis as assessed by the BI

	OR (95% CI)	p-value
Multivariate analysis after the forward stepwise method
Bun/Cr
< 15--Non-dehydration	ref
≥ 15--Dehydration	0.58(0.35–0.98)	0.041^*
Sex
Female	ref
Male	1.59(0.92–2.77)	0.097
Infection
No	ref
Yes	0.34(0.19–0.62)	<0.001^*
Proteinuria
No	ref
Yes	0.42(0.25–0.71)	0.001^*
Stratified by TOAST
For Cardioembolism
Bun/Cr
< 15--Non-dehydration	ref
≥ 15--Dehydration	0.84(0.29–2.41)	0.743
Sex
Female	ref
Male	3.31(1.22–8.98)	0.019^*
Infection
No	ref
Yes	0.39(0.13–1.16)	0.091
Proteinuria
No	ref
Yes	0.15(0.05–0.43)	<0.001^*
For Lacune
Bun/Cr
< 15--Non-dehydration	ref
≥ 15--Dehydration	0.63(0.18–2.18)	0.470
Sex
Female	ref
Male	0.82(0.23–2.93)	0.755
Infection
No	ref
Yes	0.76(0.16–3.48)	0.720
Proteinuria
No	ref
Yes	1.29(0.34–4.92)	0.708
For Large-artery atherosclerosis
Bun/Cr
< 15--Non-dehydration	ref
≥ 15--Dehydration	0.61(0.2–1.91)	0.397
Sex
Female	ref
Male	0.93(0.23–3.8)	0.914
Infection
No	ref
Yes	0.23(0.06–0.92)	0.038^*
Proteinuria
No	ref
Yes	1.08(0.31–3.82)	0.905

Abbreviations: BI Barthel Index, BUN blood urea nitrogen, Cr creatinine, mRS modified Rankin Scale. For all other abbreviations see the List of Abbreviations
* p < 0.05, significantly associated with prognosis

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