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Fig. 2 | BMC Cardiovascular Disorders

Fig. 2

From: Downregulation of Talin-1 expression associates with increased proliferation and migration of vascular smooth muscle cells in aortic dissection

Fig. 2

In vitro inhibition of Talin-1 strongly promotes VSMCs’ proliferation and migration. a Proliferation curves of VSMCs among Ad-Talin-1, Ad-GFP, Anti-Talin-1 and Anti-GFP groups. The result showed that the proliferation ability of VSMCs was significanly improved at 24 h after the treatment of adenovirus in Anti-Talin-1 group. In the contrary, Ad-Talin-1 group inhibited the proliferation ability of VSMCs when compare with Ad-GFP group (n = 5 per group). b Results of the scratch test showed that migration capability of VSMCs was improved in Anti-Talin-1 group. However, Ad-Talin-1 group didn’t significantly decreased the migration capability of VSMCs. Quantified data were presented as the number of migration cells per high-power field (n = 5 per group). c Flow cytometer analysis showed that knockdown of Talin-1 had no effect on VSMCs’ apoptosis (n = 5 per group). Data are represented as mean ± SD. All the experiments were performed thrice

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