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Table 1 Schema for the cross-over design of the study

From: Design and rationale for the WARFA trial: a randomized controlled cross-over trial testing the therapeutic equivalence of branded and generic warfarin in atrial fibrillation patients in Brazil

Periodsa

Period 1

Period 2

Period 3

Period 4

Sequences

 AABC

A

A

B

C

 BBAC

B

B

A

C

 BBCA

B

B

C

A

 AACB

A

A

C

B

 CCAB

C

C

A

B

 CCBA

C

C

B

A

  1. B Branded warfarin, A and C, Generic formulations of warfarin, each from a different manufacturer
  2. aEach period is one-month long
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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