Table 1 Study characteristics
Author | Acronym | Date | Blinding | Patient no. (tailored/control) | Platelet function assay | HPR cut-off |
|---|---|---|---|---|---|---|
Aleil | Â | 2008 | No | 31/62 | VASP | VASP-PRIÂ >Â 69% |
Bonello | Â | 2008 | No | 78/84 | VASP | VASP-PRIÂ >Â 50% |
Bonello | Â | 2009 | No | 215/214 | VASP | VASP-PRIÂ >Â 50% |
Aradi | DOSER | 2010 | Yes | 36/38 | LTA, 5 μM ADP | >34%AGGmax |
Price | GRAVITAS | 2010 | No | 1109/1105 | VerifyNow,P2Y12 | >230PRU |
Ari | EFFICIENT | 2011 | Yes | 47/47 | VerifyNow P2Y12 | <40%inhibition |
Hazarbasanov | Â | 2011 | No | 97/95 | VerifyNow P2Y12 | >208PRU |
Tousek | Â | 2011 | No | 30/30 | VerifyNow P2Y12 | >240PRU |
Trenk | TRIGGER-PCI | 2011 | Yes | 212/211 | VerifyNow P2Y12 | >208PRU |
Wang | Â | 2011 | No | 150/156 | VASP | VASP-PRIÂ >Â 50% |
Collet | ARCTIC | 2012 | No | 1213/1227 | VerifyNow,P2Y12 | >235PRU |
Samardzic | Â | 2014 | No | 43/44 | MEA | >46Â U |
Cayla | ANTARCTIC | 2016 | No | 435/442 | VerifyNow,P2Y12 | >208PRU |
Author | Clinical setting | Modified treatment | Intervention duration | Follow-up | ||
Aleil | Scheduled for elective coronary stenting | 150Â mg MD clopidogrel | 2Â weeks | 1Â month | ||
Bonello | Stable angina:52% NSTEMI:48% STEMI: 0% | Repeated 600Â mg clopidogrel LD | One week | 30Â days | ||
Bonello | Stable angina:48% NSTEMI:52% STEMI: 0% | Repeated 600Â mg clopidogrel LD | One week | 30Â days | ||
Aradi | Stable angina:100% | 600Â mg LD +150Â mg MD clopidogrel | 1Â month | 12Â months | ||
Price | Stable angina:60% NSTEMI:10.1% STEMI: 0.4% | 600Â mg LD +150Â mg MD clopidogrel | 6Â months | 6Â months | ||
Ari | Stable angina:100% | 150Â mg MD clopidogrel | 1Â month | 6Â months | ||
Hazarbasanov | Stable angina:43% NSTEMI:33% STEMI: 24% | 600Â mg LD +150Â mg clopidogrel | 1Â month | 6Â months | ||
Tousek | Stable angina:23% NSTEMI:34% STEMI: 43% | clopidogrel starting at 150Â mg/day with further dose increase | 1Â month | 6Â months | ||
Trenk | Stable angina:100% | 60Â mg LD +10Â mg MD Prasugrel | 6Â months | 6Â months | ||
Wang | Stable angina:80% NSTEMI:20% STEMI: 0% | increase in clopidogrel MD up to 375Â mg | 11Â months | 1Â year | ||
Collet | Scheduled for elective coronary stenting | Repeated 600Â mg clopidogrel LDÂ +Â 150Â mg MD clopidogrel/10Â mg MD Prasugrel | 12Â months | 12Â months | ||
Samardzic | Stable angina:16% NSTEMI:23%STEMI:60% | up to clopidogrel 600 mg × 2 + (75-300 mg MD) | 12 months | 12 months | ||
Cayla | Stable angina:18% NSTEMI:48%STEMI:34% | 5–10 mg MD Prasugrel | 12 months | 12 months | ||