Fig. 5
Associations between pulmonary hemodynamics and PDE5i effects. a Interpolated relationships from meta-regression analysis of the PDE5i-mediated reduction in PAP levels and the changes in peak VO2 (Δpeak VO2, mL/min/kg). b Interpolated relationships between the baseline PAP levels and the PDE5i-mediated reduction in PAP levels. Blue circles indicate the results from HFrEF trials; red circles indicate the results from HFpEF trials. Ages and proportions of male sex were used as covariates. Abbreviations: PAP, pulmonary arterial pressure; other abbreviations as in Fig. 2