Table 5 Adverse events by treatment group occurring in ≥2 patients with Down syndrome
From: Efficacy and safety of oral sildenafil in children with Down syndrome and pulmonary hypertension
Sildenafil Dose | ||||
|---|---|---|---|---|
Adverse Event, n (%) | Placebo (n = 12) | Low (n = 7) | Medium (n = 12) | High (n = 17) |
Conjunctivitis | 1 (8) | 0 | 0 | 2 (12) |
Diarrhea | 2 (17) | 1 (14) | 1 (8) | 4 (24) |
Vomiting | 0 | 1 (14) | 1 (8) | 3 (18) |
Pharyngitis | 0 | 1 (14) | 2 (17) | 0 |
Upper respiratory tract infection | 1 (8) | 2 (29) | 3 (25) | 0 |
Pneumonia, bacterial | 2 (17) | 0 | 0 | 0 |
Headache | 1 (8) | 1 (14) | 1 (8) | 2 (12) |