Table 5 Multivariable Cox proportional hazards models for 6-month, 12-month, and overall mortality
From: The clinical epidemiology of fatigue in newly diagnosed heart failure
6-Month HR (95% CI) | 12-Month HR (95% CI) | Overall HR (95% CI) | |
|---|---|---|---|
Fatigue | |||
Unadjusted | 1.49 (1.31, 1.70) | 1.39 (1.26, 1.54) | 1.20 (1.14, 1.27) |
Adjusted | 1.12 (0.96, 1.30) | 1.07 (0.95, 1.21 | 1.00 (0.94, 1.06) |
1) Age (per 5 year increase) | 1.19 (1.15, 1.25) | 1.19 (1.15, 1.23) | 1.25 (1.23, 1.26) |
2) Anemia | 1.60 (1.35, 1.90) | 1.46 (1.28, 1.67) | 1.18 (1.11, 1.26) |
3) Dyspnea | 1.62 (1.37, 1.92) | 1.48 (1.30, 1.69) | 1.18 (1.12, 1.26) |
4) BMI (per 5 kg/m2 increase) | 0.84 (0.79, 0.90) | 0.82 (0.77, 0.86) | 0.92 (0.89, 0.94) |
5) Hypopotassemia | 1.41 (1.20, 1.67) | 1.32 (1.15, 1.50) | 1.17 (1.08, 1.26) |
6) Volume depletion | 1.43 (1.19, 1.72) | 1.35 (1.16, 1.56) | 1.28 (1.18, 1.39) |
7) Abnormal weight loss | 1.40 (1.16, 1.68) | 1.41 (1.22, 1.63) | 1.34 (1.23, 1.46) |
8) Cerebrovascular disease | 1.24 (1.07, 1.43) | 1.28 (1.14, 1.44) | 1.25 (1.18, 1.32) |
9) Palpitations | 0.73 (0.58, 0.94) | 0.71 (0.59, 0.86) | 0.72 (0.65, 0.80) |
10) Female | 0.84 (0.72, 0.98) | 0.84 (0.75, 0.95) | 0.81 (0.77, 0.86) |
11) Syncope | 0.86 (0.73, 1.00) | 0.87 (0.77, 0.99) | 0.93 (0.87, 0.99) |
12) Sleep apnea | 0.77 (0.59, 1.00) | 0.89 (0.73, 1.08) | 0.96 (0.87, 1.06) |
13) Depression | 1.14 (0.97, 1.34) | 1.20 (1.05, 1.36) | 1.18 (1.10, 1.26) |
14) Edema | 1.12 (0.97, 1.30) | 1.24 (1.10, 1.38) | 1.21 (1.14, 1.28) |
15) Chest pain | 0.92 (0.79, 1.07) | 0.97 (0.86, 1.09) | 0.88 (0.83, 0.93) |
16) Vitamin D deficiency | 0.90 (0.74, 1.10) | 0.94 (0.81, 1.11) | 1.12 (1.01, 1.23) |
17) Hematocrit (H-NL vs. NL) | 0.79 (0.45, 1.40) | 0.93 (0.62, 1.39) | 1.04 (0.87, 1.25) |
18) Gastroesophageal reflux | 0.98 (0.85, 1.14) | 0.92 (0.82, 1.04) | 0.94 (0.89, 1.00) |