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Table 3 Multiple COX regression model for the time-cumulated exposure to systolic blood pressure and to diastolic blood pressure in relation to the new-onset of diabetes in 874 (12.7%) individuals out of 6869 participants with impaired glucose tolerance at the baseline examinations

From: Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus

New-onset of diabetes in participants with impaired glucose tolerance at the baseline examinations

Quartiles of cumulative systolic blood pressure (cumSBP)

Each increase in cumSBP by 10 mmHg·/ year

P-trend

 

Q1

Q2

Q3

Q4

cumSBP (Median) (mmHg x Year)

446.9

498.9

539.2

620.4

  

Number of Participants (n)

181 (9.7%)

148 (11.1%)

155 (13.4%)

390 (15.5%)

 

<0.001

Model 1

1.00

1.32 (1.06, 1.64)

1.69 (1.35, 2.10)

2.45 (2.00, 2.99)

1.04 (1.03, 1.04)

<0.001

Model 2

1.00

1.34 (1.08, 168)

1.70 (1.36, 2.12)

2.37 (1.93, 2.92)

1.04 (1.03, 1.04)

<0.001

Model 3

1.00

1.22 (0.97, 1.54)

1.47 (1.16, 1.86)

2.01 (1.62, 2.50)

1.03 (1.03, 1.04)

<0.001

New-onset of diabetes in participants with impaired glucose tolerance at the baseline examinations

      
 

Q1

Q2

Q3

Q4

Each increase in cumDBP by 5 mmHg·/ year

P-trend

cumDBP (Median) (mmHg x Year)

299.2

329.5

349.5

391.8

  

Number of Participants (n)

228 (10.5%)

123 (11.2%)

139 (12.4%)

384 (15.5%)

 

<0.001

Model 1

1.00

1.17 (0.93, 1.46)

1.45 (1.17, 1.80)

2.40 (2.01, 2.85)

1.03 (1.03, 1.04)

<0.001

Model 2

1.00

1.19 (00.95, 1.49)

1.48 (1.19, 1.84)

2.36 (1.97, 2.82)

1.03 (1.03, 1.04)

<0.001

Model 3

1.00

1.10 (0.87, 1.39)

1.28 (1.02, 1.60)

2.06 (1.70, 2.49)

1.03 (1.02, 1.03)

<0.001

  1. CumSBP: Q 1:cumSBP < 480mmHgxyear,Q 2:480mmHgxyear ≤ cumSBP < 520mmHgxyear,Q 3:520mmHgxyear ≤ cumSBP < 560mmHgxyear,Q 4: cumSBP ≥ 560mmHgxyear
  2. CumDBP: Q 1:cumDBP < 320mmHgxyear,Q 2:320mmHgxyear ≤ cumDBP < 340mmHgxyear,Q 3:340mmHgxyear ≤ cumDBP < 360mmHgxyear,Q 4: cumDBP ≥ 360mmHgxyear
  3. Model 1: adjusted for sex and age (years)
  4. Model 2: adjusted for model 1 and further adjusted for smoking, drinking, exercises, education and taking pressure-lowering drugs
  5. Model 3: adjusted for model 2 and further adjusted for heart rate, body mass index, and fasting serum concentration of glucose, triglycerides, high-sensitive C-reactive protein, high-density lipoproteins, low-density lipoproteins and uric acid concentration