Fig. 5
From: miR-21 enhances cardiac fibrotic remodeling and fibroblast proliferation via CADM1/STAT3 pathway
miR-21 negative control CADM1 expression. a Real-time PCR showed that transfection miR-21 mimic decreased the expression of CADM1 mRNA in cardiac fibroblasts cells. miR-21 mimic group is decreased significantly compare with vehicle group. b Western blotting indicated that transfection miR-21 mimic decreased the expression of CADM1 protein in cardiac fibroblasts cells. c Real-time PCR showed that transfection miR-21 inhibitor increased the expression of CADM1 mRNA in cardiac fibroblasts cells. miR-21 inhibitor group is increased significantly compare with vehicle group. d Western blotting indicated that transfection miR-21 inhibitor increased the expression of CADM1 protein in cardiac fibroblasts. Data are representative of at least three separate experiments. *P < 0.05, **P < 0.01 versus vehicle