Fig. 3
From: miR-21 enhances cardiac fibrotic remodeling and fibroblast proliferation via CADM1/STAT3 pathway
miR-21 increased in activated cardiac fibroblasts and fibrotic remodeling. a The miR-21 expression was assayed in rat and human cardiac fibrosis tissue. One Step Real-time PCR showed that miR-21 was significantly up-regulated in cardiac fibrosis tissue compared to vehicle tissue. Moreover, One Step Real-time PCR showed that miR-21 was significantly up-regulated in AF tissue compared to SR tissue. b The miR-21 expression was assayed in CFs stimulated with TGF-β1. One Step Real-time PCR showed that miR-21 was significantly increased in activated CFs compared to control group cell. Data are representative of at least three separate experiments. *P < 0.05 versus control or Vehicle or SR