Table 4 Multivariable-adjusted associations of allopurinol use with incident composite outcome (MI and stroke)
From: Allopurinol use and the risk of acute cardiovascular events in patients with gout and diabetes
| Â | Incident MI or stroke | |
|---|---|---|
| Â | Hazard ratio (95% CI) | p-value |
Allopurinol User | ||
 Current | 0.67 (0.53, 0.84) | 0.0006 |
 Previous | Ref |  |
Gender | ||
 Male | 1.00 (0.80, 1.26) | 0.99 |
 Female | Ref |  |
Age, in years | ||
  ≤ 50 | 0.40 (0.17, 0.93) | 0.03 |
 51–60 | 0.85 (0.49, 1.49) | 0.57 |
 66–70 | 0.88 (0.54, 1.45) | 0.61 |
 71–75 | 1.64 (1.02, 2.62) | 0.04 |
 76–80 | 1.59 (0.97, 2.60) | 0.07 |
  > 80 | 2.70 (1.69, 4.34) | <0.0001 |
 61–65 | Ref |  |
Race | ||
 Asian | 0.92 (0.54, 1.55) | 0.74 |
 Black | 0.97 (0.72, 1.31) | 0.84 |
 Hispanic | 1.41 (0.76, 2.59) | 0.27 |
 Other | 1.55 (0.79, 3.03) | 0.20 |
 Missing | 0.71 (0.36, 1.40) | 0.32 |
 White | Ref |  |
Comorbidity | ||
 Hypertension | 0.96 (0.69, 1.35) | 0.83 |
 Hyperlipidemia | 0.91 (0.69, 1.20) | 0.51 |
 COPD | 1.07 (0.74, 1.55) | 0.73 |
 Renal disease | 1.36 (1.07, 1.73) | 0.01 |
 PVD | 0.93 (0.63, 1.39) | 0.74 |