Bleeding events associated with a low dose (110 mg) versus a high dose (150 mg) of dabigatran in patients treated for atrial fibrillation: a systematic review and meta-analysis

Table 4 Results of this analysis

Outcomes	OR with 95% CI	P value	I² (%)
MI	0.93 [0.59–1.44]	0.73	0
Pulmonary embolism	0.94 [0.37–2.41]	0.90	0
Life-threatening bleeding	1.19 [0.98–1.45]	0.07	0
Extracranial bleeding	1.16 [1.01–1.33]	0.03	0
Fatal bleeding	1.12 [0.69–1.82]	0.65	0
Minor bleeding	1.19 [1.10–1.27]	0.00001	0
Intracranial bleeding	1.24 [0.82–1.88]	0.31	31
Mortality	0.41 [0.34–0.50]	0.00001	37
Intracerebral bleeding	0.85 [0.44–1.65]	0.64	45
Ischemic stroke	0.77 [0.51–1.16]	0.21	48
Major bleeding	1.09 [0.86–1.37]	0.49	57
Stroke or SE	0.93 [0.60–1.46]	0.76	59
GI bleeding	0.93 [0.55–1.58]	0.79	89

Abbreviations: MI myocardial infarction, SE systemic embolism, GI gastro-intestinal

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